This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.
還沒有人留下心得,快來搶頭香!
為您推薦
類似書籍推薦給您
類似書籍推薦給您
【簡介】 For more than four decades, Molecular Biology of the Cell has distilled the vast amount of scientific knowledge to illuminate basic principles, enduring concepts and cutting-edge research. The Seventh Edition has been extensively revised and updated with the latest research, and has been thoroughly vetted by experts and instructors. The classic companion text, The Problems Book, has been reimagined as the Digital Problems Book in Smartwork, an interactive digital assessment course with a wide selection of questions and automatic-grading functionality. The digital format with embedded animations and dynamic question types makes the Digital Problems Book in Smartwork easier to assign than ever before—for both in-person and online classes. Bruce Alberts Bruce Alberts received his PhD from Harvard University and is the Chancellor’s Leadership Chair in Biochemistry and Biophysics for Science and Education, University of California, San Francisco. He was the editor in chief of Science magazine from 2008 until 2013, and for 12 years he served as president of the U.S. National Academy of Sciences (1993–2005). Rebecca Heald Rebecca Heald is an American professor of cell and developmental biology. She is currently a professor in the Department of Molecular and Cell Biology at the University of California, Berkeley. In May 2019, she was elected to the National Academy of Sciences. Alexander Johnson Alexander Johnson received his PhD from Harvard University and is a professor of microbiology and immunology at the University of California, San Francisco. He is a member of the National Academy of Sciences. David Morgan David Morgan received his PhD from the University of California, San Francisco, and is a professor in the Department of Physiology as well as the vice dean for research for the School of Medicine. Dave is a fellow of the Royal Society of London. 【目錄】 Chapter 1: Cells, Genomes, and the Diversity of Life Chapter 2: Cell Chemistry and Bioenergetics Chapter 3: Proteins Chapter 4: DNA, Chromosomes, and Genomes Chapter 5: DNA Replication, Repair, and Recombination Chapter 6: How Cells Read the Genome: From DNA to Protein Chapter 7: Control of Gene Expression Chapter 8: Analyzing Cells, Molecules, and Systems Chapter 9: Visualizing Cells and Their Molecules Chapter 10: Membrane Structure Chapter 11: Small-Molecule Transport and Electrical Properties of Membranes Chapter 12: Intracellular Organization and Protein Sorting Chapter 13: Intracellular Membrane Traffic Chapter 14: Energy Conversion and Metabolic Compartmentation: Mitochondria and Chloroplasts Chapter 15: Cell Signaling Chapter 16: The Cytoskeleton Chapter 17: The Cell Cycle Chapter 18: Cell Death Chapter 19: Cell Junctions and the Extracellular Matrix Chapter 20: Cancer Chapter 21: Development of Multicelluar Organisms Chapter 22: Stem Cells in Tissue Homeostasis and Regeneration Chapter 23: Pathogens and Infection Chapter 24: The Innate and Adaptive Immune Systems
類似書籍推薦給您
Molecular Biology of Cancer:Mechanisms, Targets, and Therapeutics ISBN13:9780198833024 出版社:Oxford University Press 作者:Lauren (Principal Lecturer in Cancer Biology Pecorino Principal Lecturer in Cancer Biology University of Greenwich) 裝訂/頁數:平裝/440頁 規格:18.9cm*24.6cm (高/寬) 版次:5 出版日:2021/06/15 簡介 Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students. Provides an engaging and manageable route into the complex subject of cancer biology Describes the theoretical basis of cancer biology and shows how this theory is applied to develop new cancer therapies, giving students a clear appreciation of how theoretical knowledge can be translated into therapeutic strategies Draws on the latest research in this dynamic field but presents it in a manner readily accessible to the student Available for students and institutions to purchase in a variety of formats, and is supported by online resources. New to this edition The inclusion of additional primary data from the literature provides up-to-date information about this dynamic field of research. Figures to illustrate mechanisms of DNA repair. New topics covered include extrachromosomal circular DNA as major sources of oncogene expression and tumor heterogeneity, the use of errors in RNA transcription and splicing as a new source of neoantigens for vaccines, the application of artificial intelligence to cancer imaging, and expanded applications of CRISPR, to name a few. The expanded "Pioneers in the field" feature introduces students to thirteen inspiring molecular biologists working in the field from past to present. 目錄 1: Introduction 2: The cancer genome 3: Regulation of gene expression 4: Growth factor signaling and oncogenes 5: The cell cycle 6: Tumor suppressor genes 7: Apoptosis 8: Cancer stem cells and the regulation of self-renewal and differentiation pathways: focus on colon cancer and leukemias 9: Metastasis 10: Angiogenesis 11: Reprogrammed metabolism and diet 12: Tumor immunology and immunotherapy 13:I nflammation, infection, and the microbiome 14: Strategies and tools for research and drug development
類似書籍推薦給您
資訊
工程
數學與統計學
機率與統計
自然科學
健康科學
地球與環境
建築、設計與藝術
人文與社會科學
教育
語言學習與考試
法律
會計與財務
大眾傳播
觀光與休閒餐旅
考試用書
研究方法
商業與管理
經濟學
心理學
生活
生活風格商品
參考書/測驗卷/輔材