Immunology

Blends biology, clinical science, genetics, and molecular biology of the immune system to provide a complete account of our knowledge of immunology New features include full-color artwork and design, over 50 new figures, and text that has been completely revised to reflect the very latest references Incorporates a variety of pedagogical aids to assist students in the learning process, including chapter outlines, objectives, and summaries, as well as a self-evaluation section

Preface ix Note to Reader xi 1. Introduction to the Immune System 1 2. Cells and Organs of the Immune System 27 3. Innate Immunity 61 4. Antigens and Antibodies 105 5. Antigen-Antibody Interactions and Some Experimental Systems 139 6. The Genetics of Antibody Formation and Structure 179 7. The Major Histocompatibility Complex and Development of Immunity 213 8. The T-Cell Receptor Complex: Characterization, Diversification, Costimulatory Molecules, Thymic Selection, and T-Cell Activation 253 9. Cytokines 285 10. Cellular Interactions: Development of Effector Functions and Their Regulation 321 11. Complement 369 12. Hypersensitivities 397 13. Immunologic Tolerance and Autoimmunity 431 14. Transplantation Immunology 461 15. Tumor Immunology 489 16. Immunodeficiencies 529 17. Immunity to Microbes 561 Glossary of Commonly Used Immunologic Terms 611 Appendix: Human Cluster of Differentiation (CD) Molecules 687 Index 703