Evidence-Based Pediatric Oncology

The new and updated edition of the renowned reference for pediatric oncologists This groundbreaking text on the management of childhood cancers covers most tumor types occurring in children and young adults and provides reviews of randomized trials with commentaries on the optimum treatments for childhood cancer. Updated with evidence from the latest published reviews—and even more clinically focused than previous editions— Evidence-Based Pediatric Oncology, Third Edition places an emphasis on application of the trial findings. With increased coverage of the area of supportive care for pediatric cancer patients, each chapter opens with an expert commentary on the key clinical issues followed by a summary of trial findings. Evidence-Based Pediatric Oncology, Third Edition: • Presents evidence for the best treatment of children and adolescents with cancer • Includes commentaries from the world’s leading experts for every topic discussed • Is internationally relevant thanks to contributions from the UK, US, Canada and Australia • Places greater emphasis on supportive care and features a new extended section on antibiotic and antifungal treatments Based on information gathered from randomized trials performed after the release of the Second Edition, readers will find Evidence-Based Pediatric Oncology to be an important resource for all those treating young people with cancer.

List of contributors, vii Preface, ix List of abbreviations, x About the companion website, xv Part 1: Solid tumors 1 Rhabdomyosarcoma, 3 Katherine K. Matthay (Commentary by Meriel Jenney) 2 Osteosarcoma, 14 Katherine K. Matthay (Commentary by Maria Michelagnoli) 3 Ewing sarcoma, 25 Katherine K. Matthay (Commentary by Steven G. DuBois) 4 Wilms tumor, 34 Ananth Shankar (Commentary by Kathy Pritchard-Jones) 5 Neuroblastoma, 47 Katherine K. Matthay (Commentary by Katherine K. Matthay) 6 Hepatoblastoma, 58 Ross Pinkerton (Commentary by Penelope Brock) 7 Malignant germ cell tumors, 65 Ross Pinkerton (Commentary by Ross Pinkerton) 8 Medulloblastoma, 69 Ross Pinkerton (Commentary by Eric Bouffet) 9 Glioma, 81 Ross Pinkerton (Commentary by Joann L. Ater) 10 Non-Hodgkin lymphoma, 88 Ross Pinkerton (Commentary by Ross Pinkerton) 11 Hodgkin lymphoma, 105 Ross Pinkerton (Commentary by Cindy L. Schwartz) Part 2: Leukemia Section 1: Acute myeloid leukemia 12 Acute myeloid leukemia commentary, 119 Robert J. Arceci 13 Remission induction in acute myeloid leukemia, 126 Ananth Shankar 14 Acute myeloid leukemia consolidation, 135 Ananth Shankar 15 Maintenance treatment in acute myeloid leukemia, 137 Ananth Shankar 16 Autologous bone marrow transplantation in acute myeloid leukemia, 141 Ananth Shankar 17 Acute myeloid leukemia: miscellaneous, 144 Ananth Shankar Section 2: Childhood lymphoblastic leukemia 18 Childhood lymphoblastic leukemia commentary, 146 Vaskar Saha 19 Remission induction in childhood lymphoblastic leukemia, 154 Ananth Shankar 20 Central nervous system-directed therapy in childhood lymphoblastic leukemia, 168 Ananth Shankar 21 Maintenance treatment in childhood lymphoblastic leukemia, 180 Ananth Shankar 22 Relapsed childhood lymphoblastic leukemia, 198 Ananth Shankar 23 Postinduction therapy in adolescents and young adults with acute lymphoblastic leukemia, 204 Ananth Shankar Part 3: Supportive care in pediatric oncology 24 Colony-stimulating factors, 209 Ananth Shankar (Commentary by Victoria Grandage) 25 Cardioprotection in pediatric oncology, 230 Ananth Shankar (Commentary by Gill A. Levitt) 26 Infections in pediatric and adolescent oncology, 243 Ananth Shankar and Sara Stoneham (Commentary by Julia E. Clark) Index, 269