Innate Immune System of Skin and Oral Mucosa

An in-depth look at cutting-edge research on the body's innate immune system Innate immunity is the body's first line of protection against potential microbial, viral, and environmental attacks, and the skin and oral mucosa are two of the most powerful barriers that which we rely on to stay well. The definitive book on the subject, Innate Immune System of Skin and Oral Mucosa: Properties and Impact in Pharmaceutics, Cosmetics, and Personal Care Products provides a comprehensive overview of these systems, including coverage of antimicrobial peptides and lipids and microbial challenges and stressors that can influence innate immunity. Designed to help experts and newcomers alike in fields like dermatology, oral pathology, cosmetics, personal care, and pharmaceuticals, the book is filled with suggestions to assist research and development. Looking at the many challenges facing the innate immune system, including the impact of topically applied skin products and medications, Innate Immune System of Skin and Oral Mucosa paves the way for next generation treatment avenues, preventative approaches, and drug development.

Preface ix Contributors xi Part I Overview of Skin and Muscosal Innate Immunity: History, Ethics, and Science Chapter 1 Germ Free: Hygiene History and Consuming Antimicrobial and Antiseptic Products 3 Jennifer Tebbe-Grossman and Martha N. Gardner Chapter 2 Ethical Responsibilities in Formulating, Marketing, and Using Antimicrobial Personal Products 43 Kenneth A. Richman Chapter 3 Role of Stratum Corneum in Permeability Barrier Function and Antimicrobial Defense 59 Peter M. Elias Part II Antimicrobial Lipids and Peptides Chapter 4 Antimicrobial Lipids of the Skin and Oral Mucosa 75 Kim A. Brogden, David R. Drake, Deborah V. Dawson, Jennifer R. Hill, Carol L. Bratt, and Philip W. Wertz Chapter 5 Resident Microflora and Antimicrobial Peptides of Skin 83 Shamim A. Ansari Chapter 6 Defensins 109 Neelam Muizzudin Chapter 7 Antimicrobial Peptides of Skin and Oral Mucosa 117 Whasun O. Chung and Henrik Dommisch Chapter 8 Vernix Caseosa and Innate Immunity 145 Steven B. Hoath, Vivek Narendran, and Marty O. Visscher Part III Host Cellular Components of Innate Immunity Chapter 9 Sentinel Role of Mast Cells in Innate Immunity 173 Zhenping Wang and Anna Di Nardo Chapter 10 Cellular Immunity of the Skin: Langerhans Cells and Dendritic Cells 195 Karen E. Burke and Niroshana Anandasabapathy Part IV Innate Immunity Response to Stress and Aging Chapter 11 Changes in Skin Immunity with Age and Disease 217 Barbara Geusens, Iles Mollet, Chris D. Anderson, Sarah Terras, Michael S. Roberts, and Jo Lambert Chapter 12 Epidermis as a Sheild from Radiation and Oxidative Stress 259 Giuseppe Valacchi Chapter 13 The Impact of the Skin’s Innate Immunity by Cosmetic Products Applied to the Skin and Scalp 275 Rudranath Persaud and Thomas Re Chapter 14 UV-Induced Immunosuppression of Skin 281 Roger L. McMullen Part V Innate Immunity Microbial Challenges Chapter 15 Deranged Antimicrobial Barrier in Atopic Dermatitis: Roles of Sphingosine, Hexadecenoic Acid, and Beta-Defensine-2 307 Gangi Imokawa Chapter 16 Resident Microflora of the Skin and Oral Mucosa 325 David R. Drake Chapter 17 Corynebacterium Species and Their Role in the Generation of Human Malodor 333 Carol L. Bratt and Nava Dayan Index 351