Biocatalysis for Green Chemistry and Chemical Process Development

This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

Contributors vii Preface xi Part I. Introduction Chapters 1 1. Biotechnology Tools for Green Synthesis: Enzymes, Metabolic Pathways, and Their Improvement by Engineering 3 2. How Green Can the Industry Become with Biotechnology? 23 3. Emerging Enzymes and Their Synthetic Applications 45 4. Reaction Efficiencies and Green Chemistry Metrics of Biotransformations 67 Part II. Application and Case Studies-Pharmaceuticals and Fine Chemicals 89 5. Biocatalytic Routes to Chiral Intermediates for Development of Drugs 91 6. Transglutaminase for Protein Drug Modification: Pegylation and Beyond 151 7. Microbial Production of Plant-Derived Pharmaceutical Natural Products Through Metabolic Engineering: Artemisinin and Beyond 173 8. Toward Greener Therapeutic Proteins 197 Part III. Application and Case Studies-Flavor & Fragrance, Agrochemicals and Fine Chemicals 221 9. Opportunities for Biocatalysis in the Flavor, Fragrance, and Cosmetic Industry 223 10. Application of Biocatalysis in the Agrochemical Industry 255 11. Green Porduction of Fine Chemicals by Isolated Enzymes 277 12. Whole Cell Production of Fine Chemicals and Intermediates 299 Part IV. Application and Case Studies-Polymers and Renewable Chemicals 327 13. Green Chemistry for the Production of Biodegradable, Biorenewable, Biocompatible, and Polymers 329 14. Enzymatic Degradation of Lignocellulosic Biomass 361 15. Bioconversion of Nenewables-Plant Oils 391 16. Microbial Bioprocesses for industrial-Scale Chemical Production 429 Index 469