Clinical Virology

The essential reference of clinical virology Virology is one of the most dynamic and rapidly changing fields of clinical medicine. For example, sequencing techniques from human specimens have identified numerous new members of several virus families, including new polyomaviruses, orthomyxoviruses, and bunyaviruses. Clinical Virology, Fourth Edition, has been extensively revised and updated to incorporate the latest developments and relevant research. Chapters written by internationally recognized experts cover novel viruses, pathogenesis, epidemiology, diagnosis, treatment, and prevention, organized into two major sections: Section 1 provides information regarding broad topics in virology, including immune responses, vaccinology, laboratory diagnosis, principles of antiviral therapy, and detailed considerations of important organ system manifestations and syndromes caused by viral infections. Section 2 provides overviews of specific etiologic agents and discusses their biology, epidemiology, pathogenesis of disease causation, clinical manifestations, laboratory diagnosis, and management. Clinical Virology provides the critical information scientists and health care professionals require about all aspects of this rapidly evolving field.

CHAPTER 1 Introduction (Pages: 1-5) Douglas D. Richman, Richard J. Whitley, Frederick J. Hayden Section I : Viral Syndromes and General Principles CHAPTER 2 Respiratory Infections (Pages: 7-29) John J. Treanor CHAPTER 3 Viral Infections of the Central Nervous System (Pages: 31-45) Kevin A Cassady, Richard J. Whitley CHAPTER 4 Gastrointestinal Syndromes (Pages: 47-59) Eyal Leshem, Umesh D. Parashar CHAPTER 5 Viral Hepatitis (Pages: 61-73) Zina S. Valaydon, Stephen A. Locarnini, Alexander J.V. Thompson CHAPTER 6 Viral Infections in Organ Transplant Recipients (Pages: 75-98) John A. Zaia CHAPTER 7 Viral Heart Disease (Pages: 99-113) Bruce M. McMaus, Michael Seidman, Karin Klingel, Honglin Luo CHAPTER 8 Viral Diseases of the Skin (Pages: 115-139) Zeena Y. Nawas, Stephen K. Tyring CHAPTER 9 Viral Hemorrhagic Fevers (Pages: 141-150) Gail Carson, Mike Bray, Cathy Roth CHAPTER 10 Viral Disease of the Eye (Pages: 151-167) Howard M. Newman CHAPTER 11Antiretroviral Agent (Pages: 169-214) Christine J. Kubin, Barbara S. Taylor, Scott M. Hammer CHAPTER 12 Antiherpesvirus Agents (Pages: 215-237) Claire L. Gordon, Christine J. Kubin, Scott M. Hammer CHAPTER 13 Anti-Hepatitis Virus Agents (Pages: 239-270) Matthew L. Scherer, Chelsea Sammons, Brian Nelson, Scott M. Hammer, Elizabeth Verna CHAPTER 14 Antirespiratory Virus Agents (Pages: 271-290) Marcus R. Pereira, Benjamin A. Miko, Monica Mehta, Scott M. Hammer CHAPTER 15 Diagnosis of Viral Infections (Pages: 291-319) Guy Boivin, Tony Mazzulli, Martin Petric CHAPTER 16 Immune Responses to Viral Infection (Pages: 321-350) Hendrik Streeck, Todd J. Suscovich, Galit Alter CHAPTER 17 Immunization Against Viral Diseases (Pages: 351-370) Julie E. Ledgerwood, Barney S. Graham CHAPTER 18 Chronic Fatigue and Postinfective Fatigue Syndromes (Pages: 371-384) Andrew R. Lloyd Section II : The Agents Part A : DNA VIRUSES CHAPTER 19 Poxviruses (Pages: 385-413) Stuart N. Isaacs, R. Mark Buller CHAPTER 20Herpes Simplex Viruses (Pages: 415-445) Richard J. Whitley, Bernard Roizman CHAPTER 21 Cercopithecine Herpesvirus 1 (B Virus) (Pages: 447-457) Richard J. Whitley CHAPTER 22 Varicella-Zoster Virus (Pages: 459-480) Anne A. Gershon, Michael D. Gershon CHAPTER 23 Cytomegalovirus (Pages: 481-510) Paul David Griffiths, Matthew Reeves CHAPTER 24 Human Herpesvirus 6 and Human Herpesvirus 7 (Pages: 511-522) Koichi Yamanishi, Yasuko Mori CHAPTER 25 Epstein-Barr Virus (Pages: 523-547) Joyce Fingeroth CHAPTER 26 Kaposi's Sarcoma-Associated Herpesvirus (KSHV/HHV8) (Pages: 549-574) Yuan Chang, Shou-Jiang Gao, Patrick S. Moore CHAPTER 27 Adenoviruses (Pages: 575-597) Olli Ruuskanen, Jordan P. Metcalf, Matti Waris, Göran Akusjärvi CHAPTER 28 Polyomaviruses (Pages: 599-623) John E. Greenlee, Hans H. Hirsch CHAPTER 29 Papillomavirus (Pages: 625-678) William Bonnez CHAPTER 30 Human Parvoviruses (Pages: 679-699) Maria SÖderlund-Venermo, Kevin E. Brown, Dean D. Erdman CHAPTER 31 Anelloviridae (Pages: 701-711) Peter Simmonds, Colin P. Sharp CHAPTER 32 Hepatitis B Virus (Pages: 713-770) Darren J. Wong, Stephen A. Locarnini, Alexander J.V. Thompson Part B : RNA VIRUSES CHAPTER 33 Human Lymphotropic Viruses: HTLV-1 and HTLV-2 (Pages: 771-794) Roberta L. Bruhn, Renaud Mahieux, Edward L. Murphy CHAPTER 34 Human Immunodeficiency Virus (Pages: 795-840) John C. Guatelli, Robert F. Siliciano, Daniel R. Kuritzkes, Douglas D. Richman CHAPTER 35 Colorado Tick Fever and Other Arthropod Borne Reoviridae (Pages: 841-852) Steven Yukl, Joseph K. Wong CHAPTER 36 Rotaviruses (Pages: 853-872) Manuel A. Franco, Juana Angel, Harry B. Greenberg CHAPTER 37 Respiratory Syncytial Virus, Human Metapneumovirus, and Parainfluenza Viruses (Pages: 873-902) John V. Williams, Pedro A. Piedra, Janet A. Englund CHAPTER 38 Measles (Pages: 903-928) William J. Moss, Diane E. Griffin CHAPTER 39 Mumps Virus (Pages: 929-948) John W. Gnann Jr., Donald R. Latner CHAPTER 40 Zoonotic Paramyxoviruses (Pages: 949-966) Danielle E. Anderson, Lin-Fa Wang CHAPTER 41 Rhabdoviruses (Pages: 967-979) Alan C. Jackson CHAPTER 42 Filoviruses (Pages: 981-1007) Mike Bray, Daniel S. Chertow CHAPTER 43 Influenza Virus (Pages: 1009-1058) Frederick G. Hayden, Peter Palese CHAPTER 44 Bunyaviridae: Orthobunyaviruses, Phleboviruses, Nairoviruses, and Hantaviruses (Pages: 1059-1087) Gregory J. Mertz, Clas Ahlm, Colleen B. Jonsson CHAPTER 45 Arenaviruses (Pages: 1089-1111) Daniel G. Bausch CHAPTER 46 Enteroviruses (Pages: 1113-1142) JosÉ R. Romero CHAPTER 47 Rhinovirus (Pages: 1143-1164) Wai-Ming Lee, James E. Gern CHAPTER 48 Hepatitis A Virus (Pages: 1165-1188) Sara E. Williford, Stanley M. Lemon CHAPTER 49 Human Caliciviruses (Pages: 1189-1208) Robert L. Atmar, Mary K. Estes CHAPTER 50 Hepatitis E Virus (Pages: 1209-1229) Harry R. Dalton, Nassim Kamar, Jacques Izopet CHAPTER 51 Astrovirus (Pages: 1231-1242) Carlos F. Arias, TOMÁS LÓPEZ CHAPTER 52 Coronaviruses (Pages: 1243-1265) J.S.M. Peiris CHAPTER 53 Arthropod-Borne Flaviviruses (Pages: 1267-1311) Lyle R. Petersen, Alan D.T. Barrett CHAPTER 54 Hepatitis C Virus (Pages: 1313-1345) Christopher Koh, Qisheng Li, Jake Liang CHAPTER 55 Alphaviruses (Pages: 1347-1379) David W. Smith, John S. Mackenzie, Ilya V. Frolov, Scott C. Weaver CHAPTER 56 Rubella Virus (Pages: 1381-1393) David W. Kimberlin CHAPTER 57 Infections Caused by Bornaviruses (Pages: 1395-1407) Ralf DÜrrwald, Norbert Nowotny, Martin Beer, Jens H. Kuhn Part C : SUBVIRAL AGENTS CHAPTER 58 Hepatitis D (Pages: 1409-1423) Mario Rizzetto, Antonina Smedile, Alessia Ciancio CHAPTER 59 Prion Diseases (Pages: 1425-1448) Christina J. Sigurdson, Mee-Ohk Kim, Michael D. Geschwind Subject Index (Pages: 1449-1489)