Effects of Genome Structure and Sequence on the Generation of Variation and Evolution, Volume 1267

The structure of DNA varies along its sequence, which can lead to sequence-dependent variations in the fidelity of DNA copying and repair. And because the probability of distinct classes of mutations varies along a DNA sequence, variation that affects fitness will have evolutionary implications, as selection acts on heritable variation. This Annals volume brings together a broad interdisciplinary group of researchers to explore the impact of increasing understanding of DNA structure, repair, replication, and organization on interrelated subjects ranging from evolution, to dependence of the effect of mutagens on environmental and sequence context, to noncanonical forms of information representation in genomes. NOTE: Annals volumes are avaialble for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Joun.aspx for more information about becoming a member.

Overview of the creative genome: effects of genome structure and sequence on the generation of variation and evolution 1. Lynn Helena Caporale Genome hyperevolution and the success of a parasite 11. J. David Barry, James P. J. Hall, and Lindsey Plenderleith The tricky path to recombining X and Y chromosomes in meiosis 18. Liisa Kauppi, Maria Jasin, and Scott Keeney Sites of genetic instability in mitosis and cancer 24. Anne M. Casper, Danielle M. Rosen, and Kaveri D. Rajula The genome: an isochore ensemble and it’s evolution  31. Giorgio Bernardi Multiple levels of meaning in DNA sequences, and one more 35. Edward N. Trifonov, Zeev Volkovich, and Zakharia M. Frenkel Evolution of simple sequence repeat-mediated phase variation in bacterial genomes 39. Christopher D. Bayliss and Michael E. Palmer Indirect selection of implicit mutation protocols 45. David G. King G4 motifs in human genes 53. Nancy Maizels Adaptive radiation of venomous marine snail lineages and the accelerated evolution of venom peptide genes 61. Baldomero M. Olivera, Maren Watkins, Pradip Bandyopadhyay, Julita S. Imperial, Edgar P. Heimer de la Cotera, Manual B. Aguilar, Estuardo Lopez Vera, Gisela P. Concepcion, and Arturo Lluisma Integrons and gene cassettes: hotspots of diversity in bacterial genomes 71. Ruth M. Hall Creative deaminases, self-inflicted damage, and genome evolution 79. Silvestro G. Conticello Three-dimensional architecture of the IgH locus facilitates class switch recombination 86. Amy L. Kenter, Scott Feldman, Robert Wuerffel, Ikbel Achour, Lili Wang, and Satyendra Kumar Preaching about the converted: how meiotic gene conversion influences genomic diversity 95. Francesca Cole, Scott Keeney, and Maria Jasin Gross chromosomal rearrangement mediated by DNA replication in stressed cells: evidence from Escherichia coli 103. J.M. Moore, Hallie Wimberly, P.C. Thorton, Susan M. Rosenberg, and P.J. Hastings Implications of genetic heterogeneity in cancer 110. Michael W. Schmitt, Marc J. Prindle, and Lawrence A. Loeb Corrigendum for Ann. N.Y. Acad. Sci. 2009. 1182: 47-57 117.