Handbook of Radiopharmaceuticals

The thoroughly updated new edition of the authoritative reference in Radiopharmaceutical Sciences The second edition of Handbook of Radiopharmaceuticals is a comprehensive review of the field, presenting up-to-date coverage of central topics such as radionuclide production, synthetic methodology, radiopharmaceutical development and regulations, and a wide range of practical applications. A valuable reference work for those new to the Radiopharmaceutical Sciences and experienced professionals alike, this volume explores the latest concepts and issues involving both targeted diagnostic and therapeutic radiopharmaceuticals. Contributions from a team of experts from across sub-disciplines provide readers with an immersive examination of radiochemistry, nuclear medicine, molecular imaging, and more. Since the first edition of the Handbook was published, Nuclear Medicine and Radiopharmaceutical Sciences have undergone major changes. New radiopharmaceuticals for diagnosis and therapy have been approved by the FDA, the number of clinical PET and SPECT scans have increased significantly, and advances in Artificial Intelligence have dramatically improved research techniques. This fully revised edition reflects the current state of the field and features substantially updated and expanded content. New chapters cover topics including current Good Manufacturing Practice (cGMP), regulatory oversight, novel approaches to quality control—ensuring that readers are informed of the exciting developments of recent years. This important resource: Features extensive new and revised content throughout Covers key areas of application for diagnosis and therapy in oncology, neurology, and cardiology Emphasizes the multidisciplinary nature of Radiopharmaceutical Sciences Discusses how drug companies are using modern radiopharmaceutical imaging techniques to support drug discovery Examines current and emerging applications of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Edited by recognized experts in radiochemistry and PET imaging, Handbook of Radiopharmaceuticals: Radiochemistry and Applications, 2nd Edition is an indispensable reference for post-doctoral fellows, research scientists, and professionals in the pharmaceutical industry, and for academics, graduate students, and newcomers in the field of radiopharmaceuticals.

Foreword Preface List of Contributors About the Editors Abbreviations PART I: INTRODUCTION TO RADIOPHARMACEUTICALS 1. Targeted Diagnostic Radiopharmaceuticals: Design Options for Small Molecule Radiotracers Michael R. Kilbourn 2. Concepts and Issues for Therapeutic Radiopharmaceuticals Alexandra R. Sowa Dumond and Peter J. H. Scott PART II: PRODUCTION OF RADIONUCLIDES 3. Production of Short Half-life PET Radionuclides Michael R. Kilbourn, Melissa E. Rodnick and Mara Clark 4. Production of Radionuclides used in SPECT Salma Jivan and Thomas J. Ruth 5. Production of Therapeutic Radionuclides C. Shaun Loveless and Suzanne E. Lapi PART III: SYNTHETIC METHODS FOR RADIOPHARMACEUTICALS 6. Synthesis of 13N- and 15O-labeled Radiopharmaceuticals Krishna R. Pulagam, Vanessa Gómez-Vallejo, Fernando López-Gallego, Luka Rejc and Jordi Llop 7. Radiochemistry with Carbon-11 Stephen Thompson, Steven Kealey, Selena M. Sephton and Franklin I. Aigbirhio 8. Fluorine-18 Radiochemistry Allen F. Brooks, Katarina J. Makaravage, Jay Wright, Melanie S. Sanford and Peter J. H. Scott 9. Synthesis of 68Ga-labeled Radiopharmaceuticals Benjamin P. Burke and Stephen J. Archibald  10. Cu-Mediated Radiohalogenation of Organoboranes Sean W. Reilly and Robert H. Mach 11. The radiochemistry of zirconium Jason P. Holland 12. 99mTc Radiopharmaceutical Chemistry Dionysia Papagiannopoulou PART IV: PRACTICAL ASPECTS OF RADIOPHARMACEUTICAL PRODUCTION AND USE 13. Automated Synthesis Modules for PET Radiochemistry Laura Bruton and Peter J. H. Scott 14. Automation of PET Radiopharmaceutical Quality Control Arkadij Elizarov 15. Moving PET Drugs from the Lab to the Patient in USA David W. Dick 16. Moving from the Lab to the Patient in Asia Dae Yoon Chi 17.      Moving a radiotracer form bench to bedside in Europe Koen Vermeulen, Alfons Verbruggen, Guy Bormans and Frederik Cleeren PART V: MAJOR APPLICATIONS OF RADIOPHARMACEUTICALS 18. Radiopharmaceuticals in Oncology Jeroen A.C.M. Goos, Outi Keinänen, Brian M. Zeglis and Jason S. Lewis 19. Neurological applications of Radiopharmaceuticals Mehdi Djekidel and Nicolaas I. Bohnen 20. Cardiac Applications of Radiopharmaceuticals John P. Bois and Robert J. Gropler 21. Radiopharmaceuticals in Pediatric Nuclear Medicine Scott E. Snyder, Elizabeth R. Butch and Barry L. Shulkin 22. PET Imaging in Drug Discovery and Development David J. Donnelly INDEX