Salivary Diagnostics

Salivary Diagnostics surveys one of the most exciting areas of research in oral biology. Regarded as the mirror of the body, saliva has immense potential to yield real clinical improvements in our ability to diagnose, and hence treat, oral and systemic conditions. The composition of saliva and other oral fluids reflects the tissue fluid levels of therapeutic, hormonal, and immunological molecules, as well as the presence of markers for systemic and oral disease.

Contributors viii Foreword xv Preface xvii Acknowledgment xviii I Background and Foundation 1 Salivary Gland Development and Regeneration 3 Sarah M. Knox and Matthew P. Hoffman 2 Salivary Gland Physiology Relevant to Diagnostics 14 Victor G. Romanenko and James E. Melvin 3 Saliva: Properties and Functions 27 Arie van Nieuw Amerongen, Enno C.I. Veerman, and Arjan Vissink 4 Saliva Collectors 37 Arjan Vissink, Andy Wolff, and Enno C.I. Veerman 5 Salivary Secretion in Health and Disease 60 Michael D. Turner and Jonathan A. Ship 6 Processing and Storage of Saliva Samples 69 Enno C.I. Veerman, Arjan Vissink, David T. Wong, and Arie van Nieuw Amerongen II Saliva Diagnostics 7 Historical Perspectives and Present 79 Frank G. Oppenheim 8 Diagnostics Other Than Blood 94 Sudhir Srivastava and Karl Krueger 9 Perceptions of Saliva: Relevance to Clinical Diagnostics 104 Sreenivas Koka and David T. Wong 10 Saliva-Based Diagnostic Technologies: Highlights of the NIDCR's Program 111 Eleni Kousvelari, John T. McDevitt, Daniel Malamud, David T. Wong, and David R. Walt 11 Human Salivary Proteomics 122 Shen Hu, Markus Hardt, Susan J. Fisher, David T. Wong, John R. Yates, James E. Melvin, and Joseph A. Loo 12 Genomic Targets in Saliva 129 Bernhard G. Zimmermann, Zhanzhi Hu, and David T. Wong 13 Point-of-Care Diagnostics for Infectious diseases 136 Paul L.A.M. Corstjens, Daniel Malamud 14 Dental Caries Risk Assessment 150 Paul C. Denny and Patricia A. Denny 15 Periodontal Disease 156 Christoph A. Ramseier, Thiago Morelli, Janet S. Kinney, Meghan Dubois, Lindsay Rayburn, and William Giannobile 16 Role of Saliva in Detection of Substance Abuse 169 Uttam Garg and Lance Presley 17 Head and Neck Cancer 180 Joseph A. Califano and Suhail K. Mithani 18 Sjogren's Syndrome 189 Philip C. Fox 19 Salivary Gland Dysfunction Associated with Systemic Disease 198 Nelson L. Rhodus 20 Progression and Treatment Evaluation in Diseases Affecting Salivary Glands 214 Jiska M. Meijer, Cees G.M. Kallenberg, and Arjan Vissink 21 The Uses of Saliva in Forensic Genetics 226 Jack Ballantyne and Jane Juusola 22 SPKB—Salivary Proteome Knowledge Base: A Platform for Collaborative Proteomics Research 233 Weihong Yan, Weixia Yu, Shawn Than, Renli Qiao, D. Stott Parker, Joseph A. Loo, and David T. Wong III Saliva Diagnostics—A New Industry 23 Commercialization of Oral Fluid Products and Technologies 243 R. Sam Niedbala 24 Coverage and Reimbursement for Salivary Diagnostic Tests 255 James J. Crall 25 Saliva Diagnostics in the Dentist's and Physician's Office 263 Chakwan Siew and Milton V. Marshall 26 Salivary Hormones in Research and Diagnostics 270 Douglas A. Granger, Christine K. Fortunato, Leah C. Hibel 27 Crossroads Between Saliva Diagnostics and Salivary Gland Gene Therapy 278 Bruce J. Baum, Ana P. Cotrim, Corinne M. Goldsmith, Fumi Mineshiba, Senrong Qi, Gabor Z. Racz, Yuval Samuni, Takayuki Sugito, Antonis Voutetakis, and Changyu Zheng 28 Saliva Diagnostics—A New Industry 288 Stuart R. Smith, David T. Wong, and R. Michael Buch Index 295