The Application of Heat in Oncology

THE APPLICATION OF HEAT IN ONCOLOGY Understand the use of heat to destroy tumors with this comprehensive guide Heat is an indispensable resource in the destruction of cancerous tumors to potentially treat cancers. There are also real challenges, however, involved in the total destruction of tumors without destroying healthy tissue surrounding the tumor in the process. A detailed understanding of the propagation of thermal energy, induced heating, and tissue responses to heat is required to safely and successfully apply heat-based technologies in clinical oncology. The Application of Heat in Oncology supplies this understanding, with a thorough, comprehensive overview of the principle and practice involved. Offering both a detailed introduction to the physics and thermodynamics of induced heat and an analysis of its clinical applications, this is an essential resource for clinicians, technicians, and others in oncological practice. The Application of Heat in Oncology readers will also find: Guidelines for applying heat both safely and effectively Detailed discussion of topics including energy delivery (e.g., via RF, MW, ultrasound, laser, cryoagents, hyperthermia, nanoparticles, etc.), temperature assessment, damage assessment, image guidance, and more Summary of current practice along with suggestions for future areas of technological improvement The Application of Heat in Oncology is ideal for all clinicians working in the field of cancer treatment, including medical students, residents, researchers, engineers, radiologists, surgeons, and more.

List of Contributors xxi Preface xxv Part A Principles 1 A.1 Delivering Energy 3 1 Propagation of Radiofrequency and Microwaves in Tissue 5 Punit Prakash and Anna Bottiglieri 2 Propagation of Focused Ultrasound in Tissue 19 Gregory T. Clement 3 Propagation of Light in Tissue 31 Do-Hyun Kim 4 Mechanisms of Tissue Injury in Cryosurgery 45 John G. Baust, Kimberly L. Santucci, Kristi K. Snyder, Anthony Robilotto, and John M. Baust 5 Delivering Energy using Localized Hyperthermia Systems 73 Hana Dobsicek Trefna, Johannes Crezee, and Petra Kok 6 Role of Nanoparticles Mediated Heating in Oncology 95 Gennaro Bellizzi A.2 Assessing Temperatures 107 7 Temperature Monitoring During Thermal Treatment by Thermocouples and Thermistors: Current Status and Perspectives 109 Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena 8 Fluorescent-Decay Temperature Probes for Biomedical Applications: Theory, Techniques, and Practical Advice 121 Daryl James and Harry Vine 9 Calibration and Use of Infrared Thermal Cameras in Biological Applications 135 Michael L. Denton and Gary D. Noojin 10 Magnetic Resonance Thermometry in Oncology: Applications in Moving Organs 149 Henrik Odéen and Dennis L. Parker 11 Measuring Tissue Temperature with Ultrasound 175 Elyas Shaswary and Jahangir (Jahan) Tavakkoli 12 Current Status and Future Potential of Thermometry Based on Computed Tomography Imaging 195 Francesca De Tommasi, Carlo Massaroni, Daniela Lo Presti, Rosario Francesco Grasso, Massimiliano Carassiti, Yuman Fong, and Emiliano Schena 13 A Generic Thermal Model to Predict Temperatures in Perfused Tissues 205 Devashish Shrivastava A.3 Assessing Damage 217 14 Measuring Thermal Damage with Gross and Microscopic Pathology 219 Sharon Thomsen 15 Assessing Thermal Damage with Magnetic Resonance Imaging 251 Sara L. Johnson and Allison H. Payne 16 Ultrasound Imaging Techniques for the Evaluation of Thermal Damage 273 Jenna Osborn 17 Mathematical Models of Thermal Damage and Cell Death 289 John Pearce 18 A Novel Method to Indicate Onset of Photothermal Damage 307 Michael L. Denton, Gary D. Noojin, and Elharith M. Ahmed 19 Thermodynamic Challenges of Using Magnetic Resonance Thermometry in Measuring in vivo Temperatures and Estimating Thermal Damage in Thermal Ablation 329 Devashish Shrivastava Part B Clinical Applications 341 20 Biological and Physical Aspects of Heat Therapy 343 Abhijit Mandal, Ritusha Mishra, and Himanshu Mishra 21 Guiding Thermal Therapy with MR 359 Richard Tyc and Mark G. Torchia 22 Role of Radiofrequency Ablation and Laser-Induced Thermal Therapy in the Management of Functional Neurosurgery and Brain Lesions 377 Peter Konrad, Johnie Hodge, and Manish Ranjan 23 Radiofrequency and Microwave Thermal Ablation in Cancer Therapy and the Role of Hydrodissection 391 Arvind K. Chaturvedi 24 Role of High-Intensity Focused Ultrasound for Functional Neurosurgery and for the Management of Brain Lesions 403 Georgios A. Maragkos, Georgios Mantziaris, Shayan Moosa, and W. Jeffrey Elias 25 Role of HIFU in Cancer Management 425 Sofia Gereta, Judith Stangl-Kremser, Tenny R. Zhang, and Jim C. Hu 26 Percutaneous Cryoablation: Mechanism of Action, Clinical Applications, and Outcomes 459 Ahmed Farhan, Christopher R. Bailey, and Christos Georgiades 27 Clinical Applications of Hyperthermia 483 Himanshu Mishra, Ritusha Mishra, and Abhijit Mandal 28 Thermal Damage due to a Monopole Microwave Antenna 499 Marta Cavagnaro and Devashish Shrivastava 29 Thermal Damage with High-Intensity Focused Ultrasound 511 Devashish Shrivastava 30 Thermal Damage Due to Laser 519 Rahul Goyal and Devashish Shrivastava 31 Thermal Damage Due to Hot and Cold Surfaces 525 Devashish Shrivastava 32 MRI-Induced RF Heating Considerations for Devices and Accessories that are Partially in and Partially Out of the Human Body 533 Ran Guo, Md Zahidul Islam, Wolfgang Kainz, and Ji Chen References 542 Index 545