Personalizing Precision Medicine

The author uses decades of experience and interviews with experts in precision medicine to explain past, present, and future of precision medicine. She reviews the full continuum of personalizing precision medicine, including diagnostics, therapeutics, big data, supportive care, regulation, and reimbursement and innovation in precision medicine worldwide. Combines a unique cross section of history, current technologies, and future directions for how precision medicine has and will affect people worldwide Reviews precision medicine around the world, including the US, China, Japan, the Middle East, India, Europe, and Latin America Discusses a number of diseases areas – cancer, cardiovascular, neurodegenerative, infectious disease, pain, immunology, rare diseases Includes information and quotes from over 100 interviews with key industry experts in biotech, pharma, informatics, diagnostics, health providers, advocacy groups, and more Includes stories illustrating current issues and future promises in precision medicine for a human touch

Acknowledgments vii Introduction ix Methodology xiii About the Author xv Part 1 The History 1 1 The Right Drug, the Right Patient, the Right Time: Foundations of Precision Medicine 3 2 Decision‐Making Machines: Diagnostics in Precision Medicine 27 3 Precision Medicine around the World: Europe 37 Part 2 The Present 51 4 Our Reality Today: The Patient Journey in Precision Medicine 53 5 Toward the Day We Just Call It “Medicine”: Access to Precision Medicine 65 6 Precision Medicine around the World: Japan 81 7 Shifting Rules: Regulation and Reimbursement in Precision Medicine 89 8 Precision Medicine around the World: Latin America 105 9 Patients as the Poorest Princesses: Supportive Care in Precision Medicine 125 10 Informatics under the Hood: Information in Precision Medicine 135 11 Precision Medicine around the World: India 149 Part 3 The Future 157 12 A Personalized Stomach: Precision Medicine beyond Cancer 159 13 Consumer is King: Consumer Applications of Precision Medicine 181 14 Precision Medicine around the World: The Middle East 197 15 Sci‐Fi Potential: CRISPR as the Next Novel Frontier in Precision Medicine 207 16 Precision Medicine around the World: China 223 17 A New Hope: The Future of Precision Medicine 231 Afterword 241 Index 243