Advances Against Aspergillosis I

Aspergillosis, the leading fungal cause of mortality in immunocompromised patients, presents a serious worldwide challenge—particularly in the face of increasing antifungal resistance.  Bringing together the world’s leaders in the Aspergillus and aspergillosis fields to promote cross-disciplinary collaboration among clinicians, industry, and scientific experts, the “Advances Against Aspergillosis” conference was held January 26–28, 2012 in Istanbul, Turkey.  This first of two Annals volumes contains short reviews encapsulating recent clinical findings on aspergillosis.  Among the topics included are the application of diagnostic markers to invasive aspergillosis in children, risk stratification for invasive aspergillosis in immunocompromised patients, use of biological agents for the treatment of fungal asthma and allergic bronchopulmonary aspergillosis,   immune regulation in idiopathic bronchiectasis, and management of chronic pulmonary aspergillosis. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit: http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.

Preface for Advances Against Aspergillosis Karl V. demons David S. Perlin Malcolm Richardson vii Aspergillosis in the Clinic Application of diagnostic markers to invasive aspergillosis in children Emmanuel Roilides Zoi-Dorothea Pana 1 Azole resistance in Aspergillus: global status in Europe and Asia Sevtap Arikan-Akdagli 9 The impact of azole resistance on aspergillosis guidelines Sarah P. Georgiadou Dimitrios P. Kontoyiannis 15 Risk stratification for invasive aspergillosis in immunocompromised patients Raoul Herbrecht Pierre Bories Jean-Charles Moulin Marie-Pierre Ledoux Valérie Letscher-Bru 23 Invasive aspergillosis in the intensive care unit George Dimopoulos Frantezeska Frantzeskaki Garyfallia Poulakou Apostolos Armaganidis 31 Management of chronic pulmonary aspergillosis Koichi Izumikawa Masato Tashiro Shigeru Kohno 40 The use of biological agents for the treatment of fungal asthma and allergic bronchopulmonary aspergillosis Richard B. Moss 49 Multifocal pulmonary aspergillomas: case series and review Matthew Pendleton David W. Denning 58 Immune regulation in idiopathic bronchiectasis Rosemary J. Boyton Daniel M. Altmann 68 Aspergillus bronchitis without significant immunocompromise Ales Chrdle Sahlawati Mustakim Rowland J. Bright-Thomas Caroline G. Baxter Timothy Felton David W. Denning 73