Veterinary Clinical Immunology

A richly illustrated reference on immune-mediated diseases in dogs and cats, grounded in veterinary clinical practice Veterinary Clinical Immunology provides clear and accurate information on the ­pathogenesis, diagnosis, and treatment of immune-mediated diseases in small animals. Written by practicing clinicians for practicing clinicians, this highly practical resource contains user-friendly chapters on general and specific testing methods, common and atypical immune-mediated diseases, vaccination best practice and controversies, and more. Divided into four sections, the textbook opens with a thorough immunology primer for ­clinicians, describing innate and adaptive immunity, pathophysiology, immunogenetics, and pathogens. Subsequent sections focus on diagnostic approaches and treatments, immuno­deficiency and onco-immunology, and a range of specific immune-mediated diseases, including diseases of the hematopoietic system, the oral cavity and gastrointestinal tract, the kidneys and bladder, and the nervous and endocrine systems. Provides information directly applicable to clinical practice with emphasis on the diagnosis and management of immunological conditions Features numerous real-world case examples supported by high-quality ­images of blood smears, tissue sections, and other specimens relevant to the clinical ­pathology of immune-mediated diseases Includes access to a companion website with video clips of clinical cases and ­additional teaching resources Authored and edited by internationally-recognized experts in their respective fields Veterinary Clinical Immunology is a must-have for busy primary practitioners and ­specialists looking for a current and comprehensive reference source. It is also a valuable clinically-based textbook for undergraduate and postgraduate veterinary students, trainees, residents, and veterinary technicians and nurses.

List of Contributors vii Preface x About the Companion Website xi Section 1 A Primer for the Clinician 1 1 A Clinician’s Guide to the Immune System: Innate and Adaptive Immunity 3 Oliver A Garden 2 Pathophysiology of Immune-Mediated Disease 39 James W Swann 3 Immunogenetics: The Final Frontier 61 Lucy J Davison and Lorna J Kennedy 4 Vector-Borne Pathogens and Immune-Mediated Disease 84 Linda Kidd and Edward B Breitschwerdt Section 2 Diagnostic Approaches and Treatment 107 5 Diagnosing Immune-Mediated Disease: General Approach and Specific Tests 109 Linda Kidd and Amy L MacNeill 6 Treating Immune-Mediated Disease: What to Use and When 134 Todd M Archer and Claire L Fellman Section 3 Specific Immune-Mediated Diseases 165 7 Blood and Hematopoietic System 167 Todd M Archer 8 Musculoskeletal System 192 Karen Perry 9 Central and Peripheral Nervous System 234 Nicolas Granger and Linda Kidd 10 Urinary Tract 279 Jack S Lawson and Harriet M Syme 11 Oral Cavity and Gastrointestinal Tract 313 Karin Allenspach, Albert E Jergens, Laura van Vertloo, and Brenda L Mulherin 12 Liver, Biliary Tract, and Exocrine Pancreas 347 Penny Watson, Nick Bexfield, and Michael J Day 13 Nose, Trachea, and Bronchopulmonary System 387 Leah A Cohn, Cécile Clercx, and Michael J Day 14 Endocrine Organs 421 Lucy J Davison 15 Skin 436 Domenico Santoro 16 Eye and Adnexa 469 Màrian Matas Riera and Oliver A Garden 17 Polysystemic Autoinflammatory and Autoimmune Diseases 503 Jonathan E Fogle Section 4 Immunodeficiency, Onco-Immunology, and Vaccination 521 18 Primary Immunodeficiencies 523 James W Swann 19 Cancer Immunology 549 David R Killick 20 Vaccination 580 Alison Stickney and NJ Cave Index 615