Introduction to Macromolecular Crystallography

A comprehensive and approachable introduction to crystallography — now updated in a valuable new edition The Second Edition of this well-received book continues to offer the most concise, authoritative, and easy-to-follow introduction to the field of crystallography. Dedicated to providing a complete, basic presentation of the subject that does not assume a background in physics or math, the book's content flows logically from basic principles to methods, such as those for solving phase problems, interpretation of Patterson maps and the difference Fourier method, the fundamental theory of diffraction and the properties of crystals, and applications in determining macromolecular structure. This new edition includes a vast amount of carefully updated materials, as well as two completely new chapters on recording and compiling X-ray data and growing crystals of proteins and other macromolecules. Richly illustrated throughout to clarify difficult concepts, this book takes a non-technical approach to crystallography that is ideal for professionals and graduate students in structural biology, biophysics, biochemistry, and molecular biology who are studying the subject for the first time.

PREFACE. 1. AN OVERVIEW OF MAROMOLECUEAR CYRSTALLOGRAPHY. 2. CRYSTALLIZATRION OF MACROMOLEUCLES. 3. THE NATURE OF CRYSTALS: SYSMMETRY AND THE UNIT CELL. 4. WAVES AND THEIR PROPERTIES. 5. DIFFRACTION FROM POINTS, PLANES, MOLECULES, AND CRYSTALS. 6. INTERPRETATIN OF DIFFRACTION PATTERNS. 7. DATA COLLECTION. 8. SOLVING THE PHASE PROBLEM. 9. INTERPRETING PATTERSON MAPS. 10. ELECTRON DENSITY, REFINEMENT, AND DIFFERENCE FOURIER MAPS. BIBLIOGRAPHY. INDEX.