Pain in Osteoarthritis

An authoritative investigation of the sources and treatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.

Preface vii Acknowledgments ix Contributors xi Part I The Neuroscience of Articular Pain 1 Spinal Mechanisms Contributing to Joint Pain 3 Hans-Georg Schaible 2 Activation of Sensory Neurons in the Arthritic Joint 25 Blair D. Grubb 3 Changes in the Neural Substrate of Nociception in a Rat Derangement Model of Osteoarthritis 39 James L. Henry 4 Inflammatory Mediators and Nociception in Osteoarthritis 55 Bruce L. Kidd, Jason J. McDougall, and Julia J. Inglis 5 Phantoms in Rheumatology 73 Candida S. McCabe, Richard C. Haigh, Nicholas G. Shenker, Jenny Lewis, and David R. Blake 6 Mechanisms That Generate and Maintain Bone Cancer Pain 97 Juan Miguel Jimenez-Andrade, Monica Herrera, and Patrick W. Mantyh 7 Symmetry, T-Cells, and Neurogenic Arthritis 117 Nicholas G. Shenker, David R. Blake, Candida S. McCabe, Richard C. Haigh, and Paul I. Mapp Part II Osteoarthritis and Pain 8 Joint Mechanics in Osteoarthritis 133 Walter Herzog, Douglas Bourne, and Aliaa Rehan Youssef 9 Neuromuscular Aspects of Osteoarthritis 157 Kenneth D. Brandt 10 Pressure-Driven Intravasation of Osseous Fat in the Pathogenesis of Osteoarthritic Pain 175 Peter A. Simkin 11 Structural Correlates of Osteoarthritis Pain: Lessons From Magnetic Resonance Imaging 185 Philip G. Conaghan 12 Evidence of Sensitization to Pain in Human Osteoarthritis 199 Gunnar Ordeberg 13 Current Perspectives on the Clinical Presentation of Joint Pain in Human Osteoarthritis 211 Paul Creamer Part III Treatment of Osteoarthritic Pain 14 General Approach to Treating Osteoarthritic Pain: Targeting Biomechanics Inflammation and Nociception 229 David T. Felson 15 Neurobiological Mechanisms of Osteoarthritic Pain and Analgesic Treatment 233 Tuhina Neogi and Joachim Scholz 16 Exercise, Taping, and Bracing as Treatments for Knee Osteoarthritis Pain 255 Kim Louise Bennell, Michael Anthony Hunt, and Rana Shane Hinman 17 Treating Inflammation to Relieve Osteoarthritic Pain 285 David T. Felson Index 295