Fundamentals of Biochemistry

Fundamentals of Biochemistry, 6th edition, with new authors Destin Heilman and Stephen Woski, provides a solid biochemical foundation that is rooted in chemistry while presenting complete and balanced coverage that is clearly written and relevant to human health and disease. This edition includes new pedagogy and enhanced visuals that better adapt the text for the modern student, including a focus on enhanced self-assessment tools and scaffolding of learning outcomes throughout the text. The new authors continue the trusted pedagogy of the previous five editions and present approachable, balanced coverage to provide students with a solid biochemical foundation to prepare them for future scientific challenges. The pedagogy remains focused on biochemistry’s key theme: the relationship between structure and function, while streamlining the student experience to better focus attention on the critical subject matter. Fundamentals of Biochemistry 6e includes a significant update to the art program with modernized, more effective renderings that better enable understanding of the subject matter. New scaffolded learning outcomes in each section, and a focus on self-assessment tools, both streamline and elevate the effectiveness of the new edition as a critical learning resource for biochemistry students.

1 Introduction to the Chemistry of Life The Origin of Life Cellular Architecture Thermodynamics Problems 2 Water Physical Properties of Water Chemical Properties of Water Problems 3 Amino Acids Amino Acid Structure Stereochemistry Amino Acid Derivatives Polypeptides and Proteins Problems 4 Proteins: Three-Dimensional Structure Secondary Structure Tertiary Structure Quaternary Structure and Multiprotein Complexes Protein Folding and Unfolding Biochemistry in Focus: Oxygen Transport Problems 5 Carbohydrates Monosaccharides Polysaccharides Glycoproteins Problems 6 Nucleotides, Nucleic Acids, and Genetic Information Nucleotides and Polynucleotides Nucleic Acid Structure: DNA Nucleic Acid Structure: RNA Problems 7 Lipids and Biological Membranes Lipid Classification Lipid Bilayers Membrane Proteins Membrane Structure and Assembly Problems 8 Membrane Transport Thermodynamics of Transport Passive-Mediated Transport Active Transport Problems 9 Enzymatic Catalysis General Properties of Enzymes Enzymes Work by Lowering Activation Energy Mechanisms Lysozyme Serine Proteases Problems 10 Enzyme Kinetics, Inhibition, and Control Reaction Kinetics Enzyme Inhibition Control of Enzyme Activity Biochemistry In Focus: Enzymes as Targets for Drug Design Problems 11 Biochemical Signaling Hormones Receptor Tyrosine Kinases Heterotrimeric G Proteins The Phosphoinositide Pathway Biochemistry in Focus: Chemical Signaling and Movement Problems 12 Introduction to Metabolism Overview of Metabolism "High-Energy" Compounds Oxidation–Reduction Reactions Experimental Approaches to the Study of Metabolism Problems 13 Glucose Catabolism Overview of Glycolysis The Reactions of Glycolysis Metabolism of Hexoses Other than Glucose Fermentation: The Anaerobic Fate of Pyruvate Gluconeogenesis Regulation of Glycolysis and Gluconeogenesis The Pentose Phosphate Pathway Problems 14 Glycogen Metabolism and Gluconeogenesis Glycogen Breakdown Glycogen Synthesis Control of Glycogen Metabolism Other Carbohydrate Biosynthetic Pathways Problems 15 Citric Acid Cycle Overview of the Citric Acid Cycle Synthesis of Acetyl-SCoenzyme A Enzymes of the Citric Acid Cycle Regulation of the Citric Acid Cycle Reactions Related to the Citric Acid Cycle Problems 16 Electron Transport and Oxidative Phosphorylation The Mitochondrion Electron Transport Oxidative Phosphorylation Control of Oxidative Metabolism Biochemistry in Focus: The Mitochondrion and Cell Death Problems 17 Photosynthesis Chloroplasts The Light Reactions The Dark Reactions Problems 18 Lipid Metabolism Lipid Digestion, Absorption, and Transport Fatty Acid Oxidation Fatty Acid Biosynthesis Synthesis of Other Lipids Cholesterol Metabolism Problems 19 Amino Acid Metabolism Protein Degradation Amino Acid Deamination and the Urea Cycle Breakdown of Amino Acids Amino Acid Biosynthesis Other Products of Amino Acid Metabolism Biochemistry in Focus: Nitrogen Fixation Problems 20 Mammalian Fuel Metabolism: Integration & Regulation Organ Specialization Hormonal Control of Fuel Metabolism Metabolic Homeostasis: The Regulation of Energy Metabolism, Appetite, and Body Weight Disturbances in Fuel Metabolism Problems 21 Nucleotide Metabolism Synthesis of Purine Ribonucleotides Synthesis of Pyrimidine Ribonucleotides Formation of Deoxyribonucleotides Nucleotide Degradation Problems 22 DNA Replication Overview of DNA Replication Prokaryotic DNA Replication Eukaryotic DNA Replication Problems 23 DNA Repair and Recombination DNA Damage DNA Repair Recombination and Transposons Problems 24 Transcription and RNA Processing Prokaryotic RNA Transcription Transcription in Eukaryotes Posttranscriptional Processing Problems 25 Protein Synthesis The Genetic Code Transfer RNA and Its Aminoacylation Ribosomes Translation Posttranslational Processing Problems 26 Regulation of Gene Expression Genome Organization Regulation of Prokaryotic Gene Expression Regulation of Eukaryotic Gene Expression The Cell Cycle, Cancer, Apoptosis, and Development Appendix: Methods