Introduction to Pharmaceutical Analytical Chemistry

Primary source for learning pharmaceutical analytical chemistry, fully updated and revised to reflect current practice and Pharmacopoeia standards Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques, and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products, and drug substances in biological fluids. Extensively revised throughout to reflect the current European Pharmacopoeia (Ph.Eur) and United States Pharmacopeia (USP), this Third Edition presents updated methodologies, practical examples, and calculations to reflect current pharmaceutical laboratory practice. Revisions to the chapter structure, text, and figures have been implemented to improve clarity and comprehension. New practice problems, up-to-date practical examples, and detailed illustrations are also included throughout the text. Written by a team of experienced academics, Introduction to Pharmaceutical Analytical Chemistry explores topics including: Fundamentals of bases, acids, solubility, polarity, partition, stereochemistry, and pharmaceutical analytical chemistry Marketing authorizations, pharmaceutical manufacturing, titration, UV-Vis spectrophotometry, IR spectrophotometry, and atomic spectrometry Separation principles in liquid chromatography, high-performance liquid chromatography, gas chromatography, electrophoretic methods, and mass spectrometry Sample preparation, quality of analytical data and validation, and chemical analysis of pharmaceutical ingredients and preparations Bioanalysis chemical analysis of pharmaceuticals in biological fluids and chemical analysis of biopharmaceuticals Introduction to Pharmaceutical Analytical Chemistry is essential reading for chemists, biochemists, and other scientists entering the pharmaceutical industry, along with undergraduate and graduate students enrolled in pharmaceutical courses.

Preface to the Third Edition xiii Symbols and Units xv Chapter 1: The Link Between Pharmaceuticals and Analytical Chemistry 1 Chapter 2: The Link between Pharmaceutical Substances and Pharmacopoeias 15 Chapter 3: Chemical and Physicochemical Properties of Pharmaceutical Substances and Reagents 39 Chapter 4: Fundamentals of Pharmaceutical Analytical Chemistry 59 Chapter 5: Titration 97 Chapter 6: Introduction to Spectroscopic Methods 121 Chapter 7: UV-Vis Spectrophotometry 130 Chapter 8: Infrared Spectrophotometry 150 Chapter 9: Atomic Spectrometry 161 Chapter 10: Introduction to Chromatography 175 Chapter 11: Separation Principles in Liquid Chromatography 190 Chapter 12: High-Performance Liquid Chromatography 215 Chapter 13: Gas Chromatography 230 Chapter 14: Electrophoretic Methods 246 Chapter 15: Mass Spectrometry 262 Chapter 16: Sample Preparation 290 Chapter 17: Data Quality, Quantification and Validation 311 Chapter 18: Chemical Analysis of Pharmaceutical Substances 337 Chapter 19: Chemical Analysis of Pharmaceutical Products 380 Chapter 20: Bioanalysis 415 20.1 Biological Fluids: Composition, Sample Collection and Storage 416 Chapter 21: Chemical Analysis of Biopharmaceuticals 432 Index 469