Essential Biochemistry

Essential Biochemistry, 5th Edition, combines succinct and clear chapters with extensive problem sets. Students benefit from a modern approach involving broad, but not overwhelming coverage of biochemical facts, focusing on the chemistry behind biology. Students are provided with practical knowledge and problem-solving opportunities. Because effective learning also requires students to become as fully engaged with the material as possible, the authors have employed a strategy of posing questions and suggesting study activities throughout each chapter, so that students will not simply read and memorize but will explore and discover on their own — a truer reflection of how biochemists approach their work in the laboratory or clinic.

Preface xiv Part 1 Foundations 1 The Chemical Basis of Life 1 2 Aqueous Chemistry 27 Part 2 Molecular Structure and Function 3 Nucleic Acid Structure and Function 57 4 Protein Structure 86 5 Protein Function 125 6 How Enzymes Work 167 7 Enzyme Kinetics and Inhibition 198 8 Lipids and Membranes 234 9 Membrane Transport 258 10 Signaling 287 11 Carbohydrates 315 Part 3 Metabolism 12 Metabolism and Bioenergetics 337 13 Glucose Metabolism 366 14 The Citric Acid Cycle 403 15 Oxidative Phosphorylation 428 16 Photosynthesis 458 17 Lipid Metabolism 483 18 Nitrogen Metabolism 518 19 Regulation of Mammalian Fuel Metabolism 555 Part 4 Genetic Information 20 DNA Replication and Repair 582 21 Transcription and RNA 627 22 Protein Synthesis 663 Glossary G-1 Odd-Numbered Solutions S-1 Index i-1