When Cells Die II

Cell death is fast becoming one of the most dynamic areas of biological research-involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods-making it difficult for scientists to get an overview of the field. When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death offers the most thorough, cutting-edge coverage of this field since publication of the acclaimed first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised to include major advances in research, this new edition features relevant discussion of: * The impact of genomics and proteomics * Gene therapy and pharmacogenetics * The role of mitochondria * Caspase-independent and non-apoptotic cell death * Evolution of mechanisms With the manipulation of programmed cell death in clinical situations now in the foreseeable future, When Cells Die II also addresses the role of apoptosis in specific organ systems-the immune system, nervous system, and gastrointestinal tract-as well as different disease states, including viral infection, cancer, and myocardial infarct. Expertly edited to provide detailed cross-referencing, consistency of style, and a logical progression of topics, When Cells Die II is the definitive resource for understanding current cell death science. It will prove an invaluable text for advanced undergraduate, graduate, and medical students, postdoctoral fellows, scientists, and clinicians in cell biology, immunology, developmental biology, neuroscience, and cancer research.

Contributors vii Preface xi Section I Cell Death Origin and Progression 1 Introduction 3 Richard A. Lockshin and Zahra Zakeri Section II Biological Role of Cell Death in Development and Homeostasis 2 Cell Death: Shaping an Embryo 27 Zahra Zakeri and Richard A. Lockshin 3 Cell Death in Dictyostelium: Assessing a Genetic Approach 59 Jean-Pierre Levraud, Myriam Adam, Marie-Françoise Luciani, Laurence Aubry, Gérard Klein, and Pierre Golstein 4 Programmed Cell Death in Drosophila Melanogaster 79 Loretta Dorstyn and Sharad Kumar 5 Cell Death in Plant Development and Defense 99 Ron Mittler and Alice Y. Cheung 6 Regulation of Apoptosis by Extracellular Matrix During Postembryonic Development in Xenopus Laevis 123 Atsuko Ishizuya-Oka, Tosikazu Amano, Liezhen Fu, and Yun-Bo Shi 7 Apoptosis in the Immune System 143 Alexandra Brás, David García-Domingo, and Carlos Martinez-A. 8 Cell Death in Neuronal Development and Maintenance 175 Aviva M. Tolkovsky, Edward T. W. Bampton, and Cristoph G. Goemans 9 Cell Turnover: Intestine and other Tissues 201 James W. Wilson and Christopher S. Potten 10 Cell Death, Aging Phenotypes, and Models of Premature Aging 241 Huber R. Warner Section III How Cell Death Is Carried Out 11 Survival Factors 257 David L. Vaux 12 Caspase-independent and Autophagic Programmed Cell Death 275 Wilfried Bursch, Adolf Ellinger, Christopher Gerner, and Rolf Schulte-Hermann 13 The Recognition and Engulfment of Apoptotic Cells by Phagocytes 311 Raymond B. Birge 14 Cell Cycle Genes: pRb and P53 339 Nianli Sang and Antonio Giordano 15 Mitochondria and Oxidation in the Regulation of Cell Death 381 John D. Robertson, Sten Orrenius, and Boris Zhivotovsky Section IV Deregulation of Cell Death in Disease and Future Intervention 16 the Use of Proteomics to Identify and Characterize Cell Death Proteins 405 Xavier Saelens, Geert van Loo, Kris Gevaert, Joel Vanderkerckhove, and Peter Vandenabeele 17 Cell Death in Viral Infections, 435 Ying-bei Chen, Yihru Fannjiang, and J. Marie Hardwick 18 Cell Death in Cancer and Cancer Therapy 461 Simone Fulda and Klaus-Michael Debatin 19 the Role of Apoptosis in Myocardial Infarction and Heart Failure 483 Kartik Mani, Chang-Fu Peng, Gregg Rosner, and Richard N. Kitsis Index 521