Spectroscopic Methods for Determining Protein Structure in Solution

This book is concerned with applications of spectroscopic methods to determine protein structure in solution. The methods which are covered include virtually every method which involves the interaction of electromagnetic radiation with proteins in solution and the chapters are written by acknowledged experts from industry and academic institutions. The reader will be able to use this book to decide which spectroscopic techniques will be applicable to the problem he is faced with and be referred to the primary literature which should be most helpful.

From the Contents: Overview of Protein Structure and Spectroscopic Methods/ Protein Structure Analysis Using Circular Dichroism/ Energy Transfer Methods for Determining Distance Distributions in Proteins/ Applications of Global Analysis to Time-Resolved Fluorescene Spectroscopy of Proteins/ Zero-Order and Derivative Ultraviolet Absorption Techniques for Investigating Protein Tertiary Structure/ Protein Structure as Revealed by Non-Resonance Raman Spectroscopy/ Probes of Local Protein Structure with Resonance Raman Spetroscopy/ Infrared Absorption Methods for Examining Protein Structure/ Protein Structure Investigations with Vibrational Circular Dichroism Spectroscopy/ Proton NMR Studies of Medium-Size Proteins in Solution/ Protein Dynamics from a Theoretical Perspective.