Microbial Biofilms

An examination of the research and translational application to prevent and treat biofilm-associated diseases In the decade since the first edition of Microbial Biofilms was published, the interest in this field has expanded, spurring breakthrough research that has advanced the treatment of biofilm-associated diseases. This second edition takes the reader on an exciting, extensive review of bacterial and fungal biofilms, ranging from basic molecular interactions to innovative therapies, with particular emphasis on the division of labor in biofilms, new approaches to combat the threat of microbial biofilms, and how biofilms evade the host defense. Chapters written by established investigators cover recent findings, and contributions from investigators new to the field provide unique and fresh insights. Specifically, Microbial Biofilms provides state-of-the-art research in the field of bacterial and fungal biofilms detailed descriptions of the in vitro and in vivo models available to evaluate microbial biofilms future areas of research and their translational and clinical applications Microbial Biofilms is a useful reference for researchers and clinicians. It will also provide insight in the dynamic field of microbial biofilms for graduate and postgraduate students.

Contributors vii Preface xiii Acknowledgments xv 1 New Technologies for Studying Biofilms 1 Michael J. Franklin, Connie Chang, Tatsuya Akiyama, and Brian Bothner 2 Fungal Biofilms: In Vivo Models for Discovery of Anti-Biofilm Drugs 33 Jeniel E. Nett and David R. Andes 3 Biofilm Development 51 Tim Tolker-Nielsen 4 Division of Labor in Biofilms: the Ecology of Cell Differentiation 67 Jordi van Gestel, Hera Vlamakis, and Roberto Kolter 5 Candida albicans Biofilm Development and Its Genetic Control 99 Jigar V. Desai and Aaron P. Mitchell 6 Candida Biofilms: Development, Architecture, and Resistance 115 Jyotsna Chandra and Pranab K. Mukherjee 7 Biofilm Formation by Cryptococcus neoformans 135 Luis R. Martinez and Arturo Casadevall 8 Aspergillus Biofilm In Vitro and In Vivo 149 Anne Beauvais and Jean-Paul Latgé 9 Adhesins Involved in Attachment to Abiotic Surfaces by Gram-Negative Bacteria 163 Cécile Berne, Adrien Ducret, Gail G. Hardy, and Yves V. Brun 10 Biofilm Matrix Proteins 201 Jiunn N. C. Fong and Fitnat H. Yildiz 11 Bacterial Extracellular Polysaccharides in Biofilm Formation and Function 223 Dominique H. Limoli, Christopher J. Jones, and Daniel J. Wozniak 12 The Biology of the Escherichia coli Extracellular Matrix 249 David A. Hufnagel, William H. DePas, and Matthew R. Chapman 13 Antimicrobial Tolerance in Biofilms 269 Philip S. Stewart 14 How Biofilms Evade Host Defenses 287 Emmanuel Roilides, Maria Simitsopoulou, Aspasia Katragkou, and Thomas J. Walsh 15 c-di-GMP and its Effects on Biofilm Formation and Dispersion: a Pseudomonas Aeruginosa Review 301 Dae-Gon Ha and George A. O'Toole 16 Mechanisms of Competition in Biofilm Communities 319 Olaya Rendueles and Jean-Marc Ghigo 17 Dispersal from Microbial Biofilms 343 Nicolas Barraud, Staff an Kjelleberg, and Scott A. Rice 18 Chemical Biology Strategies for Biofilm Control 363 Liang Yang and Michael Givskov 19 From Biology to Drug Development: New Approaches to Combat the Threat of Fungal Biofilms 373 Christopher G. Pierce, Anand Srinivasan, Anand K. Ramasubramanian, and José L. López-Ribot Index 389