Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting

This book combines emulsion knowledge into a single, comprehensive volume, ideal for professionals and students involved in the areas of pharmaceutical science who are looking to learn about this emergent research concept. Compiles the step-by-step investigations made concerning the potential of nanosized emulsions on both drug delivery and drug targeting areas by different group of scientists in various laboratories across the world Inverts the common nano-emulsions coverage trend of focusing on focused on the particulate system itself, instead exploring the way to turn nanosized emulsions as biomedical tool, as well as, treating the in vitro and in vivo aspects after administration Provides an overview of the current state-of-the art regarding the development of tocol emulsions, emulsion adjuvants in immunization research, oxygen-carrying emulsions (called as fluorocarbon emulsion) and emulsions for delivering drugs to nasal and topical (ocular and transdermal) routes

List of Contributors ix Foreword xi Preface xiii 1. Introduction: An Overview of Nanosized Emulsions 1 2. Formulation Development of Oil-In-Water Nanosized Emulsions 19 3. Characterization and Safety Assessment F Oil-In-Water Nanosized Emulsions 69 4. Manufacturing and Positioning (Generations) of Oil-In-Water Nanosized Emulsions 169 5. Biofate of Nanosized Emulsions 225 6. Medical or Therapeutical Applications of Oil-In-Water Nanosized Emulsions 259 Part I: Overview of Tocol-Based Emulsions, Oxygen-Carrying Emulsions, Emulsions With Double or Triple Cargos and Emulsion-Like Dispersions 287 7. Overview of Tocol‐Based Emulsions, Oxygen‐Carrying Emulsions, Emulsions With Double or Triple Cargos and Emulsion‐Like Dispersions 289 7.1. Tocol-Based Nanosized Emulsions 291 7.2. Oxygen-Carrying Emulsions 301 7.3. Nanosized Emulsions For Multiple Medicament Loadings, Imaging, and Theranostic Purposes 321 7.4. Emulsion-Like Dispersions 347 Part II: Selected Case Studies 369 8. Selected Case Studies 371 8.1. Case Study 1 - Cationic Nanosized Emulsions: Narration of Commercial Success 373 8.2. Case Study 2 - Fish Oil-Based Nanosized Emulsions 389 Index 423