Raman, Infrared, and Near-Infrared Chemical Imaging

An all-inclusive guide on the analytical methods of Raman, infrared, and near-infrared chemical imaging An underutilized technology, chemical imaging through Raman, infrared (IR), and near-infrared (NIR) is beginning to gain recognition for its non-destructive method of permitting visualization of spatially resolved chemical information. This type of analysis is triggering a groundswell of demand as manufactured materials become more complex and the need for greater scrutiny and less damaging research practices is at a premium. Concentrating on the applications of chemical imaging, this book presents a thorough background on the theory, software, and hardware employed in this analytical technique. With full examination of this rapidly growing field, this book: Combines many different aspects and applications into one comprehensive volume Discusses how chemical imaging techniques have expanded greatly in terms of instruments and applications, but have lagged in general awareness among scientists and industries that would benefit the most from them Describes chemical imaging uses in key areas—biomedical, pharmaceutical, food, and polymer research Has chapters that outline hardware and instrumentation for the different methods of chemical imaging Encapsulating analytic methods without complicating the subject matter, this book shows where chemical imaging has been successfully applied, inspiring researchers to cultivate the exciting capabilities rooted within this powerful and multifaceted technology.

Preface vii Contributors ix 1. Spectroscopic Theory for Chemical Imaging 1 M. J. Pelletier and C. C. Pelletier Part I Hardware 21 2. Raman Imaging Instrumentation 23 Matthew P. Nelson and Patrick J. Treado 3. FT-IR Imaging Hardware 55 J. Sellors, R. A. Hoult, R. A. Crocombe, and N. A. Wright 4. Technologies and Practical Considerations for Implementing Near-Infrared Chemical Imaging 75 E. Neil Lewis and Linda H. Kidder 5. Data Analysis and Chemometrics for Hyperspectral Imaging 93 Paul Geladi, Hans Grahn, and Marena Manley Part II Biomedical Applications 109 6. Biomedical Applications of Raman Imaging 111 Michael D. Morris and Gurjit S. Mandair 7. Skin Pharmacology and Cosmetic Science Applications of IR Spectroscopy, Microscopy, and Imaging 133 Richard Mendelsohn, Carol R. Flach, David J. Moore, and Laurence Senak 8. Near-Infrared In Vivo Spectroscopic Imaging: Biomedical Research and Clinical Applications 149 R. Anthony Shaw, Valery V. Kupriyanov, Olga Jilkina, and Michael G. Sowa Part III Pharmaceutical Applications 167 9. Pharmaceutical Applications of Raman Chemical Imaging 169 Slobodan Šašić and Lin Zhang 10. Applications of FTIR Spectroscopic Imaging in Pharmaceutical Science 185 Sergei G. Kazarian and Patrick S. Wray 11. NIR Imaging Applications in the Pharmaceutical Industry 205 Ad Gerich, Janie Dubois, and Linda H. Kidder Part IV Applications in Food Research 227 12. Raman and Infrared Imaging of Foods 229 Nils Kristian Afseth and Ulrike Böker 13. Near-Infrared Hyperspectral Imaging in Food Research 243 Paul Geladi and Marena Manley Part V Applications in Polymer Research 261 14. Vibrational Spectroscopy Imaging in Polymers 263 Harumi Sato, Yukihiro Ozaki, Jianhui Jiang, Ru-Qin Yu, and Hideyuki Shinzawa Part VI Special Methods 283 15. Surface-Enhanced Raman Scattering Imaging: Application and Experimental Approach by Far-Field with Conventional Setup 285 Yasutaka Kitahama, Mohammad Kamal Hossain, Yukihiro Ozaki, Tamitake Itoh, Athiyanathil Sujith, and Xiaoxia Han 16. Linear and Nonlinear Raman Microspectroscopy: From a Molecule to Single Living Cells 301 Hideaki Kano, Yu-San Huang, Yasuaki Naito, Rintaro Shimada, and Hiro-o Hamaguchi Index 313