Cancer

A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms. With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book: Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications Contains contributions from leaders in cancer research, care, and clinical trials Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient Focuses on the importance of cancer prevention, early detection, treatment, and survivorship Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.

List of Contributors ix Preface xv Part I: Cancer and the Cancer Experience 1 1 Cancer and the Cancer Experience 3 Gary S. Stein and Kimberly P. Luebbers Part II: Current Understanding of Cancer Biology 13 2 Cancer Biology and Pathology 15 G. Premveer Reddy, Lekkala V. Reddy, and Sahn‐Ho Kim 3 Causes of Cancer: Genetic, Epigenetic, Viral, Microenvironmental, and Environmental Contributions to Cancer 53 Michaela Reagan Part III: A Cancer Diagnosis 75 4 Early Warning Signs 77 Solomon A. Graf and F. Marc Stewart 5 Importance of Imaging for Diagnosis and Treatment of Cancer 89 Kristin DeStigter, Sally Herschorn, Anant Bhave, Benjamin Lange, and Sean Reynolds 6 Cancer Biomarkers 107 Robert H. Getzenberg 7 Molecular Diagnosis 123 Mark F. Evans Part IV: Navigating the Cancer Experience 145 8 Navigating the Cancer Experience 147 David C. Nalepinski Part V: Clinical Dimensions to Cancer 167 9 Classification of Tumors, Their Frequency and Progression 169 Richard C. Zieren, Liang Dong, Sarah R. Amend, and Kenneth J. Pienta 10 Cancer Epidemiology: Identifying Cancer Risk 213 Bernard F. Cole, Brian L. Sprague, Thomas P. Ahern, and Judy R. Rees Part VI: Tumor Types 227 11 Breast Cancer: Unique Characteristics as Targets for Therapy 229 Ogheneruona Apoe, Ted James, Gabriella Szalayova, Amrita Pandit, and Marie E. Wood 12 Prostate Cancer 245 David W. Sobel and Mark K. Plante 13 Gastrointestinal Cancer 259 Kristina Guyton, Baddr Shakhsheer, and Neil Hyman 14 Lung Cancer 271 Farrah B. Khan, C. Matthew Kinsey, and Garth Garrison 15 Pediatric Oncology 285 Jessica L. Heath 16 Leukemia, Lymphoma, and Myeloma 299 Alan Rosmarin 17 GU Oncology: Kidney, Urothelial, and Penile Cancer 317 Scott Perrapato 18 Liver Cancer: Hepatocellular Carcinoma 327 Jennifer LaFemina, Bradley Switzer, and Giles F. Whalen 19 GYN Oncology: Unique Characteristic Targets for Therapy in Gynecologic Cancers 345 Celeste Straight, Leslie Bradford, and Susan Zweizig 20 Testicular Cancer 365 Christopher B. Allard and Michael L. Blute 21 Head and Neck Cancer 379 Kumar G. Prasad, Marion Couch, and Michael Moore 22 Brain and Spinal Cord Tumors 395 Lawrence Recht 23 Thyroid Cancer 415 Frances E. Carr Part VII: Treatment Options 445 24 Radiation Therapy 447 Thomas J. FitzGerald, Maryann Bishop‐Jodoin, Fran Laurie, Christopher Riberdy, Jesse N. Aronowitz, Elizabeth Bannon, Bruce A. Bornstein, Carla D. Bradford, Harry Bushe, Maria G. Cicchetti, Linda Ding, Jonathan M. Glanzman, David J. Goff, Beth B. Herrick, Jessica R. Hiatt, I‐Lin Kuo, Yuan‐Chyuan Lo, Janaki Moni, Richard S. Pieters, Paul S. Rava, Allison Sacher, Jonathan Saleeby, Shirin Sioshansi, Kenneth Ulin, John M. Varlotto, and Tao Wang 25 Radiation Therapy – The Patient Experience 463 Harold James Wallace, III 26 Pain Management in Cancer 481 Carlos A. Pino 27 Complementary and Alternative Medicine 499 Phil Trabulsy 28 Gene Therapy 531 Mai K. ElMallah, Michael Kalfopolous, and Terence R. Flotte Part VIII: Patient Resources 553 29 Cancer‐Center‐Based Care 555 George J. Weiner 30 Supportive Care 563 Kathleen McBeth 31 Investigating Cancer Sentiments across Social Media 573 Eric M. Clark, W. Christian Crannell, Jesse Moore, Ted James, Mitchell Norotsky, and Chris A. Jones Part IX: The Path to Reducing the Cancer Burden: Prevention, Early Detection, Recovery, Survivorship 591 32 Cancer Genetics: Risk Assessment 593 Wendy McKinnon 33 Cancer Prevention: Diet, Nutrition, and Lifestyle 603 Jennifer L. May and Jean R. Harvey 34 Cancer Survivorship 617 David Cranmer 35 The Tools of Advocacy in Cancer Prevention, Early Detection, Recovery, and Treatment 621 Jill Sudhoff‐Guerin Index 637