Systems Biology and Livestock Science

Systems Biology is an interdisciplinary approach to the study of life made possible through the explosion of molecular data made available through the genome revolution and the simultaneous development of computational technologies that allow us to interpret these large data sets. Systems Biology has changed the way biological science views and studies life and has been implemented in research efforts across the biological sciences. Systems Biology and Livestock Science will be the first book to review the latest advances using this research methodology in efforts to improve the efficiency, health, and quality of livestock production. Systems Biology and Livestock Science opens with useful introductory chapters explaining key systems biology principles. The chapters then progress to look at specific advances in fields across livestock science. Coverage includes, but is not limited to, chapters on systems biology approaches to animal nutrition, reproduction, health and disease, and animal physiology. Written by leading researchers in the field, Systems Biology and Livestock Science, will be an invaluable resource to researchers, professionals, and advance students working in this rapidly developing discipline.

List of Contributors vii Preface xi Chapter 1. Introduction to Systems Biology for Animal Scientists 1 Christopher K. Tuggle, Fadi Towfic, and Vasant G. Honavar Chapter 2. Modeling Approaches in Systems Biology, Including Silicon Cell Models 31 Alexey N. Kolodkin, Fred C. Boogerd, Frank J. Bruggeman, and Hans V. Westerhoff Chapter 3. The IUPS Physiome Project: A Worldwide Systems Biology Initiative 53 Gregory O’Grady, Peng Du, and Leo K. Cheng Chapter 4. Systems Biology in Livestock Health and Disease 83 Gordon M. Kirby Chapter 5. Systems Biology of Host–Food–Microbe Interactions in the Mammalian Gut 109 Vitor A.P. Martins dos Santos, Michael Muller, Willem M. de Vos, Jerry Wells, Marinus F.W. te Pas, Guido Hooiveld, Peter van Baarlen, Mari A. Smits, and Jaap Keijer Chapter 6. From Visual Biological Models Toward Mathematical Models of the Biology of Complex Traits 137 Marinus F.W. te Pas, Arend J.W. Hoekman, and Ina Hulsegge Chapter 7. Molecular Networks as Sensors and Drivers of Uterine Receptivity in Livestock 161 Stefan Bauersachs and Eckhard Wolf Chapter 8. Modeling Approaches to Link Various Levels of Organization in Animal Physiology 191 Andre Bannink, James France, and Jan Dijkstra Chapter 9. Systems Biology and Animal Nutrition: Insights from the Dairy Cow During Growth and the Lactation Cycle 215 Juan J. Loor, Massimo Bionaz, and Guido Invernizzi Chapter 10. Host-Pathogen Interactions 247 Mari A. Smits and Dirkjan Schokker Chapter 11. Systems Biology in Livestock Science and Commercial Livestock Business 277 Marinus F.W. te Pas, Henri Woelders, and Andre Bannink Index 287