Biomarkers in Heart Disease

Biomarkers in Heart Disease is the first title in the AHA Clinical Series and is aimed at meeting the needs of clinicians, providing cardiologists, internists, emergency physicians, laboratorians, and other healthcare providers with a clear understanding of the role of biomarkers in contemporary cardiovascular medicine. The book covers both the strengths and pitfalls of currently available markers, and provides information on the most promising biomarkers that are likely to impact practice in the next few years. It is divided into four parts, organized around clinical scenarios rather than individual biomarkers. This book will help the practicing physician decide which biomarkers to measure, when to measure them, how to interpret the results and how to make decisions based on the test result.

Contributors vii Preface x Foreword xii Part I Biomarkers for the Evaluation of Patients with Ischemic Heart Disease 1 Protocols for diagnosing myocardial infarction 3 James McCord 2 Troponin and other markers of necrosis for risk stratification in patients with acute coronary syndromes 22 Thomas E. Noel and Michael C. Kontos 3 Challenges interpreting cardiac troponin values 40 Fred S. Apple 4 Natriuretic peptides and inflammatory markers for risk stratification in patients with ischemic heart disease 53 Torbjørn Omland and Torgun Wæhre 5 Novel markers in patients with suspected acute coronary syndromes 75 Renato D. Lópes, Mark Chan, and L. Kristin Newby Copyrighted Material Part II Biomarkers for Evaluation of Patients with Heart Failure 6 Use of natriuretic peptides in the diagnosis of heart failure 95 Abelardo Martinez-Rumayor and James L. Januzzi 7 Biomarkers for risk stratification in patients with heart failure 116 W. H. Wilson Tang 8 Natriuretic peptides for disease monitoring in patients with chronic heart failure 140 Richard W. Troughton and A. Mark Richards Part III Biomarkers for Screening in Ambulatory Populations 9 C-Reactive Protein 161 Amit Khera 10 Newer markers for population screening: focus on lipoprotein-related markers 181 Vijay Nambi, Ron C. Hoogeveen, and Christie Ballantyne Part IV A Look to the Future 11 Moving toward personalized medicine 207 David A. Morrow, Marc S. Sabatine, and James A. de Lemos Index 229