Chemical Biophysics:Quantitative Analysis of Cellular Systems

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Chemical Biophysics provides an engineering-based approach to biochemical system analysis for graduate-level courses on systems biology, computational bioengineering and molecular biophysics. It is the first textbook to apply rigorous physical chemistry principles to mathematical and computational modeling of biochemical systems for an interdisciplinary audience. The book is structured to show the student the basic biophysical concepts before applying this theory to computational modeling and analysis, building up to advanced topics and research. Topics explored include the kinetics of nonequilibrium open biological systems, enzyme mediated reactions, metabolic networks, biological transport processes, large-scale biochemical networks and stochastic processes in biochemical systems. End-of-chapter exercises range from confidence-building calculations to computational simulation projects.

NOBEL PRIZES: GENES, VIRUSES AND CELLULAR SIGNALING

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The present book discusses the Nobel Prizes in physiology or medicine from 1969 to 1971. The 1969 prize recognized Max Delbrück, Alfred Hershey and Salvador Luria. Their pioneering studies of viruses infecting bacteria, bacteriophages, from the mid-1940s through the 1950s laid the foundation for the wide field of molecular biology. The nature of the gene was finally understood. Insights into the biochemistry of the critical information molecules, the nucleic acids, opened wide vistas for interpreting their expression and the interaction of their product with other gene products. The contact between the endings of a nerve and a target cell, the synapse, has always stirred the imagination of scientists. A number of the insights gained have been highlighted by Nobel Prizes in physiology or medicine. In 1970 the prize recognized Bernard Katz, Ulf von Euler and Julius Axelrod. They had revealed how signaling substances in the nerve terminals were stored in packages, released by membrane fusion and inactivated or reused by particular metabolic events. The recipient of the 1971 Nobel Prize in physiology or medicine was a single scientist, Earl Sutherland. He had identified critical molecules in cells that allow signals elicited at their surface via a number of internal steps to influence the expression of specific genes in the nucleus. The new kind of information transmitting molecules were referred to as "secondary messengers". They represent a critical part of a highly complex network of signaling controlling the operative conditions of the cell by adjustments of the so-called intermediary metabolism. The widening insights into functions of specialized cells and their complex interactions have led to the development of many kinds of remedies. Sample Chapter(s) Preface Chapter 1: A Nobel Prize that Was Never Awarded Contents: A Nobel Prize that Was Never Awarded Contrasting Personalities and the Birth of a Discipline A Humble Experimentalist and Finally a Nobel Prize Advance of Knowledge is a Many-Splendored Thing The Interwar Tectonic Shift in Dominance in Natural Sciences Born to Become a Nobel Prize Recipient A Late Blooming Scientist A Prize Combination Decided by the Nobel Committee A Particular Year of Only Single Nobel Prize Recipients Readership: General.

Cellular and Molecular Immunology (10版)

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Cellular and Molecular Immunology(紙本+電子書) (10版)

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