NMR WITH BIOLOGICAL MACROMOLECULES IN SOLUTION

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The book provides insights into the research of the Kurt Wüthrich laboratories from 1996–2020. During this time period, the technique of nuclear magnetic resonance (NMR) spectroscopy in solution went through several breakthroughs, while maturing into a standard method of structural biology. With the introduction of TROSY (transverse relaxation-optimized spectroscopy), the range of accessible molecular sizes was extended about thirty-fold, and efficient protein structure determination resulted from the demands of the structural genomics initiative. Applications in fundamental biology and biomedicine include studies of prion proteins and prion diseases (TSEs), the SARS-Corona virus proteome, trans-membrane signalling by G protein-coupled receptors (GPCRs), and signal transfer by pheromones. Key publications from the Kurt Wüthrich laboratories are placed in perspective, providing insights into new aspects of NMR spectroscopy in structural biology. In addition to methods development, this includes applications in diverse areas of biological research, such as prion proteins and their role in transmissible spongiform encephalopathies (TSEs), trans-membrane signal transfer by G protein-coupled receptors (GPCRs), structural characterization of the SARS-Corona virus proteome , metabolic-flux profiling in bacterial cultures, and signal transfers by pheromones. Sample Chapter(s) Preface 1. Background and Introduction Contents: Background and Introduction NMR Methods and Software Developments Protein Folding and Protein Dynamics Prion Proteins and Transmissible Spongiform Encephalopathies (TSEs) Structural Genomics and the SARS Coronavirus (SARS-CoV) G Protein-coupled Receptors (GPCRs) Exciting Biology — Collaborations Around the Globe Acknowledgments and Appendices Readership: Faculty, postdoctoral fellows and graduate students in structural biology, biochemistry, biomedical research and NMR spectroscopy.

SCATTERING AND DIFFRACTION BY WEDGES 2 - THE WIENER-HOPF SOLUTION

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【簡介】 The book has a dual purpose. The first is to expose a general methodology to solve problems of electromagnetism in geometries constituted of angular regions. The second is to bring the solutions of some canonical problems of fundamental importance in modern electromagnetic engineering with the use of the Wiener-Hopf technique. In particular, the general mathematical methodology is very ingenious and original. It is based on sophisticated and attractive procedures exploiting simple and advanced properties of analytical functions. Once the reader has acquired the methodology, she/he can easily obtain the solution of the canonical problems reported in the book. The book can be appealing also to readers who are not directly interested in the detailed mathematical methodology and/ or in electromagnetics. In fact the same methodology can be extended to acoustics and elasticity problems. Moreover, the proposed practical problems with their solutions constitute a list of reference solutions and can be of interests in engineering production in the field of radio propagations, electromagnetic compatibility and radar technologies. 【目錄】

Instructor's Solution Manual to accompany Elementary Differential Equations and Elementary Differential Equations w/ Boundary Value Problems (9版)

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【簡介】 Written from the perspective of the applied mathematician, the latest edition of this bestselling book focuses on the theory and practical applications of Differential Equations to engineering and the sciences. Emphasis is placed on the methods of solution, analysis, and approximation. Use of technology, illustrations, and problem sets help readers develop an intuitive understanding of the material. Historical footnotes trace the development of the discipline and identify outstanding individual contributions. This book builds the foundation for anyone who needs to learn differential equations and then progress to more advanced studies. 【目錄】