GENES, GERMS AND MEDICINE: THE LIFE OF JOSHUA LEDERBERG

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Genes, Germs and Medicine explores the development of modern biomedical science in the United States through the life of one of the Twentieth Century's most influential scientists. Joshua Lederberg was a scientific renaissance man. He and his collaborators founded the field of bacterial genetics, and he was awarded the Nobel Prize at the age of 33 (the second youngest in history). He helped to lay the foundations for genetic engineering, made fundamental revisions to immunological and evolutionary theory, and developed medical genetics. He initiated the search for extraterrestrial microbial life, developed artificial intelligence, and was a visionary of the Digital Age. Lederberg coined some of the central terms of modern biology: plasmid, transduction, exobiology, euphenics and microbiome. A complex humanist who spoke out for social justice, Lederberg confronted racism, and denied a gene-centered view of humans. Pondering our social evolution outside of nature, he forewarned of the complex ethical issues arising from bioengineering. He sounded the alarm about coming pandemics at a time when few would listen, and warned of the peril of biowarfare and strove to prevent it. Lederberg was a man with a deep sense of social and intellectual responsibility, a trusted advisor to eight presidential administrations.

Genetics: From Genes to Genomes (8版)

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【簡介】 Description Genetics: From Genes to Genomes represents a new approach to an undergraduate course in genetics. It reflects the way the authors currently view the molecular basis of life. The eighth edition emphasizes both the core concepts of genetics and the cutting-edge discoveries, modern tools, and analytical methods that will keep the science of genetics moving forward. 【目錄】 Table of Contents Part I Basic Principles: How Traits Are Transmitted 1. Mendel’s Principles of Heredity 2. Extensions to Mendel’s Laws 3. Chromosome and Inheritance 4. Sex Chromosomes 5. Linkage, Recombination, and Gen Mapping Part II What Genes Are and What They Do 6. DNA Structure, Replication, and Recombination 7. Mutation 8. Using Mutations to Study Genes 9. Gene Expression: The Flow of Information from DNA to RNA to Protein Part III Analysis of Genetic Information 10. Digital Analysis of DNA 11. Genome Annotation 12. Analyzing Genomic Variation Part IV How Genes Travel on Chromosomes 13. The Eukaryotic Chromosome 14. Chromosomal Rearrangements 15. Ploidy 16. Bacterial Genetics 17. Organellar Inheritance Part V How Genes Are Regulated 18. Gene Regulation in Prokaryotes 19. Gene Regulation in Eukaryotes 20. Epigenetics Part VI Using Genetics 21. Manipulating the Genomes of Eukaryotes 22. Genetic Analysis of Development 23. The Genetics of Cancer Part VII Beyond the Individual Gene and Genome 24. Variation and Selection in Populations 25. Genetics Analysis of Complex Traits

SCIENCE, POLITICS, STEM CELLS AND GENES

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Is there a way to fight back against "incurable" disease? California thought so — and put its money where its mind was — three billion dollars' worth! And when that was gone, how about five and a half billion dollars more — to build and expand the California Institute for Regenerative Medicine? For some, science excites; it is the great adventure, to challenge the impossible: like a real-life battle with a giant squid, or the proposed disassembly of the Eiffel Tower, or ejecting from a jet in the sky, from a height greater than Mount Everest. For others, regenerative medicine is a mystery — could the urge to do murder have a genetic cause — which might be reduced? And for everyone, there is the fight to protect our loved ones' lives— 133 million of us, suffering from chronic disease — from America alone, a colossal cost of 3 trillion dollars last year. An epic battle, "Science, Politics, Stem Cells and Genes: CALIFORNIA'S WAR ON CHRONIC DISEASE" takes the reader behind the scenes. An award-winning teacher, Reed shares science in stories — including the systematic assault on Alzheimer's disease, cancer, autism, epilepsy, liver failure, schizophrenia, obesity, stroke, sickle cell, arthritis, blindness, paralysis, kidney failure, ALS, aging, and much, much more. Readers can expect a greater understanding of the intricate adventure of stem cell research, as well as the political wrestling it took to make progress possible — that California's effort may benefit the world. From early research to clinical trials, America should take pride in the accomplishments of the California Institute for Regenerative Medicine. Read on. Sample Chapter(s) Foreword 1: The Golden State, and Stem Cell Possibilities Contents: The Golden State, and Stem Cell Possibilities The Dream I Wish Had Not Come True The Shot Policeman and the Walk-again Rat The Importance of Pizza (Boxes) Please Help Change the World! "But Where Do You Keep the Babies?" Sued by an Embryo? Where I Left My Heart Muotri's Robot The Loss of a Friend, and Two Shark Stories Killer in My Classroom Dr Larry vs Alzheimer's Making a Hemo Substitute? Tarzan and the Obesity Demon Before the Lightning Strikes The Man Who Fell from the Sky Tunnels Grampa and the Lion Diagnosis and Decisions The Possibility of Cure Gloria's Last Request The Pope and the Whale The Passing of Gloria The Half-Empty House A Science Adventure Down and Out? Running in the Dark R U Latin-X? The Multiplicity Disease Fighting Forward Against the Plague Of Tigers, Pain and Sickle Cell How Many Chronic Diseases Do You Have? A Legacy of Cure A Teenage Gorilla — And the Citizen's Initiative? Protect the Nerves! Of Ninja Women Warriors, and The Fight Against Disease Son of Bob Strikes Back The Villain in Aging? 133 Million Reasons for Cure — and One More "And Care for Him, Who Shall Have Born the Battle" ... An Appreciation of Asian-American Scientists Of Crocodiles, and The Cost of Losing A Romance of Kidney Failure? Champions All Mud and Dust, Fire and Flood Nearing the Top of the Mountain Supply to the Eyes? How Roman Gets Up in the Morning A Scientist's Life for You? But Can We Afford iIt? Incurably III — for Just One Day? The Second-Most Important Matter on the Ballot Staying Out of Politics? A Child's Life Disassembling the Eiffel Tower? Your California College — Was It Helped by CIRM? What We Have Won Unfinished Business A Christmas Poem Statement from Maria T Millan, President/CEO California Institute of Regenerative Medicine An Interview with Bob Klein Readership: Stem cell researchers; patient advocates, sickle-cell sufferers, students, science teachers, scientists in biomed field, parents of children with disabilities, young people wanting a career in biomed.

NOBEL PRIZES: GENES, VIRUSES AND CELLULAR SIGNALING

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The present book discusses the Nobel Prizes in physiology or medicine from 1969 to 1971. The 1969 prize recognized Max Delbrück, Alfred Hershey and Salvador Luria. Their pioneering studies of viruses infecting bacteria, bacteriophages, from the mid-1940s through the 1950s laid the foundation for the wide field of molecular biology. The nature of the gene was finally understood. Insights into the biochemistry of the critical information molecules, the nucleic acids, opened wide vistas for interpreting their expression and the interaction of their product with other gene products. The contact between the endings of a nerve and a target cell, the synapse, has always stirred the imagination of scientists. A number of the insights gained have been highlighted by Nobel Prizes in physiology or medicine. In 1970 the prize recognized Bernard Katz, Ulf von Euler and Julius Axelrod. They had revealed how signaling substances in the nerve terminals were stored in packages, released by membrane fusion and inactivated or reused by particular metabolic events. The recipient of the 1971 Nobel Prize in physiology or medicine was a single scientist, Earl Sutherland. He had identified critical molecules in cells that allow signals elicited at their surface via a number of internal steps to influence the expression of specific genes in the nucleus. The new kind of information transmitting molecules were referred to as "secondary messengers". They represent a critical part of a highly complex network of signaling controlling the operative conditions of the cell by adjustments of the so-called intermediary metabolism. The widening insights into functions of specialized cells and their complex interactions have led to the development of many kinds of remedies. Sample Chapter(s) Preface Chapter 1: A Nobel Prize that Was Never Awarded Contents: A Nobel Prize that Was Never Awarded Contrasting Personalities and the Birth of a Discipline A Humble Experimentalist and Finally a Nobel Prize Advance of Knowledge is a Many-Splendored Thing The Interwar Tectonic Shift in Dominance in Natural Sciences Born to Become a Nobel Prize Recipient A Late Blooming Scientist A Prize Combination Decided by the Nobel Committee A Particular Year of Only Single Nobel Prize Recipients Readership: General.