Electrostatic Basis of Biological Actions (1版)

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【簡介】 In this book, Nobel Laureate Arieh Warshel introduces the microscopic basis of electrostatic theory and the ways to evaluate electrostatic energies in macromolecules. Warshel rigorously develops the theoretical framework of electrostatics, introducing a hierarchy of models from all-atom representations to continuum approximations, critically evaluating their assumptions and limitations.A major focus is placed on the electrostatic underpinnings of enzymatic catalysis, protein-ligand interactions, redox processes, and the folding and stability of proteins. The text also addresses specialized topics such as pKa calculations, ion and proton channels, and the dielectric behavior of proteins. Furthermore, we examine the electrostatic basis of molecular machines, signaling mechanisms (including G-proteins and Ras), GPCR activation, and cell-cell interactions.By integrating detailed theoretical models with biological function, Warshel provides a unifying perspective that reshapes our understanding of biomolecular action. This work serves as both a definitive reference and a forward-looking framework, emphasizing the predictive power of physically consistent electrostatic models in elucidating life at the molecular level.

Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practice (22版)

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重量：4.24kg 頁數： 2156 裝訂：精裝　開數：22*28.8 cm　印刷：彩色 紙本+access code,僅提供部份內容瀏覽非全文 (Print+Electronic Package) 原版見401-2434 For generations of trainees and surgeons at all levels of experience,Sabiston Textbook of Surgery: The Biological Basis of Modern Surgical Practicehas beenthe go-to text for definitive guidance on every aspect of general surgery. As the oldest continuously published textbook of surgery in North America, thefully revised 22nd Editioncontinues to provide the key information, essential teaching pearls, and updated content needed to make the most informed surgical decisions and achieve optimal outcomes for patients.Concisely written and evidence-based throughout, it covers the breadth of material required for certification and practice of general surgery, highlighted by detailed, full-color intraoperative illustrations and high-quality video clips. Provides detailed, practical answers and quickly accessible clinical content for surgeons at all levels, across all subspecialties―offering a one-stop, complete reference throughout a surgeon’s career, including information needed for residency and board certification. Contains new chapters on minimally invasive surgery, endoscopic techniques, simulation, and AI, as well as expanded discussions of robotic and minimally invasive approaches to surgical procedures. Follows a clear, consistent progression beginning with principles common to surgical specialties including fluid and electrolyte management, metabolic support, and wound healing; subsequent sections review the management of injury, transplantation, oncology, breast, endocrine, and abdominal procedures. Presents the underlying science and its clinical application to make informed surgical decisions and achieve optimal outcomes. Covers topics encountered by general surgery residents in training as well as in-depth coverage of subspecialty areas including head and neck, thoracic, vascular, urology, neurosurgery, pediatrics, and gynecology. Provides access to more than two dozen high-quality surgical procedure and technique videos (many are new!), new podcast-style audio resources, more than 2,000 superb images, and hundreds of quick-reference tables, boxes, and algorithms. Shares the fresh perspectives and expertise of new lead editor Dr. Douglas S. Tyler, and six new associate editors, Drs. Andrea Hayes-Dixon, O. Joe Hines, Rachel Kelz, Melina R. Kibbe, Christine Lau, and Mayur Patel.