藥物化學 (1版)

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【中文翻譯書】 書名：藥物化學 第三版 原文書名：An introduction to medicinal chemistry 3/E 原文作者：Graham L. Patrick 中文譯者：王志鉦 ISBN：9789576169229 目次 內容摘要 專欄清單 字母縮寫與簡稱 藥物的分類 藥物的命名 PART A　 藥物藥效學與藥物動力學 1藥物與藥化學家 2為什麼和為何藥物會產生作用 3蛋白質作為藥物作用標靶 4蛋白質作為藥物作用標靶：酵素 5蛋白質作為藥物作用標靶：受體 6蛋白質作為藥物作用標靶：受體結構與訊息傳遞 7 核酸作為藥物標靶 8 藥物動力學和相關主題 PART B 　藥物的發現、設計與發展 9藥物的發現：先導化合物的發現 10 藥物設計：優化作用標靶交互作用 11藥物設計：對作用標靶的優化接近 12 藥物的發展 PART C　商業工具 13 構效量化關係 14組合式合成 15電腦在藥物化學上的應用 PART D　藥物化學上選擇的主題 16 抗菌劑 17抗病　藥劑 18 抗癌藥物 19膽鹼性藥、抗膽鹼性藥物和抗膽鹼酯 20腎上腺素性神經系統 21鴉片類止痛劑 22抗潰瘍藥物 附錄一　必須胺基酸 附錄二　標準基因密碼 附錄三　構效量化關係的統計資料 附錄四　神經的作用 附錄五　微生物 附錄六　藥物與商品名 名詞解釋 一般深入閱讀

Cardiac Drugs Made Ridiculously Simple (2版)

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【簡介】 The new edition includes thoroughly revised and updated information about the latest clinical trials and guidelines in Cardiology. For medical students, house officers, cardiac fellows, practicing physicians, nurses, nurse practitioners, physician associates and other health care professionals. Cardiac drugs are the cornerstone of modern cardiovascular therapeutics. The number of cardiac drugs used for the prevention and treatment of cardiovascular disease continues to grow at an unprecedented rate. Practitioners often feel overwhelmed trying to keep pace with the plethora of cardiac drugs and the difficult decisions of which drugs to choose for which conditions. Cardiac Drugs Made Ridiculously Simple provides a lucid, practical summary of current cardiovascular drug therapy. It distills basic clinical concepts to a concise, clear minimum, while including essential information on the latest pharmacologic treatment recommendations to help guide clinical decision making in the hospital or outpatient setting. 【目錄】

The Maudsley Deprescribing Guidelines: Antidepressants, Benzodiazepines, Gabapentinoids and Z-drugs (1版)

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【簡介】 重量：1.14kg 　頁數：568 裝訂：平裝 　開數：24.3 x 16.9 cm 印刷：雙色 The Maudsley®Deprescribing Guidelines Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more. Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so. The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment. This evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts). Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors’ work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as: Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugs Barriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation process Distinguishing withdrawal symptoms, such as poor mood, anxiety, insomnia, and a variety of physical symptoms from symptoms of the underlying disorder that medication was intended to treat The difference between physical dependence and addiction/substance use disorder Explanation of why and how to implement hyperbolic tapering in clinical practice Specific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approaches Step-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individual Troubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse. Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine.

Drug Delivery Strategies for Poorly Water-Soluble Drugs

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【簡介】 Many newly proposed drugs suffer from poor water solubility, thus presenting major hurdles in the design of suitable formulations for administration to patients. Consequently, the development of techniques and materials to overcome these hurdles is a major area of research in pharmaceutical companies. Drug Delivery Strategies for Poorly Water-Soluble Drugs provides a comprehensive overview of currently used formulation strategies for hydrophobic drugs, including liposome formulation, cyclodextrin drug carriers, solid lipid nanoparticles, polymeric drug encapsulation delivery systems, self–microemulsifying drug delivery systems, nanocrystals, hydrosol colloidal dispersions, microemulsions, solid dispersions, cosolvent use, dendrimers, polymer- drug conjugates, polymeric micelles, and mesoporous silica nanoparticles. For each approach the book discusses the main instrumentation, operation principles and theoretical background, with a focus on critical formulation features and clinical studies. Finally, the book includes some recent and novel applications, scale-up considerations and regulatory issues. Drug Delivery Strategies for Poorly Water-Soluble Drugs is an essential multidisciplinary guide to this important area of drug formulation for researchers in industry and academia working in drug delivery, polymers and biomaterials. 【目錄】