Biomarkers

This book provides an introduction to the field of biomarkers, how they have been and can be used, and how different approaches can be used to identify, characterize, and monitor biomarkers. The book has chapters on topics including HIV, Cancer, Parkinson’s, vascular injury, environmental exposure. A following section discusses the technologies (diagnostics and assays) to detect biomarkers and authors have emphasized the preclinical and clinical manifestation of the injury/disease process.

Preface xxii Contributors xxv 1 Biomarkers: An Evolutionary Perspective 1 Michael Ferguson and Vishal Vaidya Section I: Tools for Biomarker Discovery 5 2 Genomics 7 Weida Tong and Donna L. Mendrick 3 Proteomics for Biomarker Discovery 25 Timothy D. Veenstra 4 Metabolic Profiling for Biomarker Discovery 47 Hector C. Keun 5 The Bittersweet Promise of Glycobiology 75 Padmaparna Chaudhuri, Rania Harfouche, and Shiladitya Sengupta Section II: Biomarkers of Injury/Disease 89 6 Biomarkers of Alzheimer's and Parkinson's Disease 91  Walter Maetzler and Daniela Berg 7 Biomarkers of Cardiac Injury 119 Anthony S. McLean and Stephen J. Huang 8 Lung Injury Biomarkers 157 Urmila P. Kodavanti 9 Translational Biomarkers of Acute Drug-Induced Liver Injury: The Current State, Gaps and Future Opportunities 203 Josef Ozer, William Reagan, Sheli Schomaker, Joe Palandra, Mike Baratta and Shashi Ramaiah 10 Biomarkers of Acute Kidney Injury 237 Frank Dieterle and Frank Sistare 11 In Search of Biomarkers for Drug-Induced Vascular Injury 281 James R. Turk 12 Biomarkers of Immunotoxicity 307 Rodney R. Dietert 13 Biomarkers in Obstetric Medicine 323 Manish Maski, Sarosh Rana and S. Ananth Karumanchi 14 Biomarkers in Cancer 355  Roopali Roy, Christine M. Coticchia, Jiang Yang and Marsha A. Moses 15 Biomarkers of HIV 381 Lewis Kaufman and Michael J Ross 16 Biomarkers of in Vitro Drug-Induced Mitochondrial Dysfunction 401 James A. Dykens and Yvonne Will Section III: Technology for Biomarker Detection 423 17 Immunoassay-Based Technologies for the Measurement of Biological Materials Used for Biomarkers Discovery and Translational Research 425 Vincent Ricchiuti 18 Nanoscale Techniques for Biomarker Quantification 457 Madhukar Varshney, and Harold G. Craighead 19 Immunodiagnostics with a Focus on Lateral Flow Point-of-Care Devices 495 Roy R. Mondesire, Glen M. Ford, Hannie F. Ford, and Stephen C. Mefferd Section IV: Hot Topics In Biomarker Research 517 20 Biomarkers for Environmental Exposure 519 Jane E. Gallagher, Elaine A. Cohen Hubal and Stephen W. Edwards 21 Clinical Study Design in Biomarker Research 549 Orfeas Liangos and Bertrand L. Jaber 22 Statistical Issues in Biomarker Research 561 Daniel Holder and Matthew Schipper 23 Regulatory Perspective for Biomarker Qualification from U.S. FDA 581 Federico Goodsaid 24 The European Medicines Agency Approach 589 Marisa Papaluca Amati and Spiros Vamvakas Index 595