Molecular Biology of Human Cancers (2版)

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This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.

Molecular Biology of the Cell (7版)

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【簡介】 For more than four decades, Molecular Biology of the Cell has distilled the vast amount of scientific knowledge to illuminate basic principles, enduring concepts and cutting-edge research. The Seventh Edition has been extensively revised and updated with the latest research, and has been thoroughly vetted by experts and instructors. The classic companion text, The Problems Book, has been reimagined as the Digital Problems Book in Smartwork, an interactive digital assessment course with a wide selection of questions and automatic-grading functionality. The digital format with embedded animations and dynamic question types makes the Digital Problems Book in Smartwork easier to assign than ever before—for both in-person and online classes. Bruce Alberts Bruce Alberts received his PhD from Harvard University and is the Chancellor’s Leadership Chair in Biochemistry and Biophysics for Science and Education, University of California, San Francisco. He was the editor in chief of Science magazine from 2008 until 2013, and for 12 years he served as president of the U.S. National Academy of Sciences (1993–2005). Rebecca Heald Rebecca Heald is an American professor of cell and developmental biology. She is currently a professor in the Department of Molecular and Cell Biology at the University of California, Berkeley. In May 2019, she was elected to the National Academy of Sciences. Alexander Johnson Alexander Johnson received his PhD from Harvard University and is a professor of microbiology and immunology at the University of California, San Francisco. He is a member of the National Academy of Sciences. David Morgan David Morgan received his PhD from the University of California, San Francisco, and is a professor in the Department of Physiology as well as the vice dean for research for the School of Medicine. Dave is a fellow of the Royal Society of London. 【目錄】 Chapter 1: Cells, Genomes, and the Diversity of Life Chapter 2: Cell Chemistry and Bioenergetics Chapter 3: Proteins Chapter 4: DNA, Chromosomes, and Genomes Chapter 5: DNA Replication, Repair, and Recombination Chapter 6: How Cells Read the Genome: From DNA to Protein Chapter 7: Control of Gene Expression Chapter 8: Analyzing Cells, Molecules, and Systems Chapter 9: Visualizing Cells and Their Molecules Chapter 10: Membrane Structure Chapter 11: Small-Molecule Transport and Electrical Properties of Membranes Chapter 12: Intracellular Organization and Protein Sorting Chapter 13: Intracellular Membrane Traffic Chapter 14: Energy Conversion and Metabolic Compartmentation: Mitochondria and Chloroplasts Chapter 15: Cell Signaling Chapter 16: The Cytoskeleton Chapter 17: The Cell Cycle Chapter 18: Cell Death Chapter 19: Cell Junctions and the Extracellular Matrix Chapter 20: Cancer Chapter 21: Development of Multicelluar Organisms Chapter 22: Stem Cells in Tissue Homeostasis and Regeneration Chapter 23: Pathogens and Infection Chapter 24: The Innate and Adaptive Immune Systems