This comprehensive textbook provides the fundamental concepts and methods of dissipative quantum mechanics and related issues in condensed matter physics starting from first principles. It deals with the phenomena and theory of decoherence, relaxation and dissipation in quantum mechanics that arise from the random exchange of energy with the environment. Major theoretical advances in combination with stunning experimental achievements and the arising perspective for quantum computing have brightened the field and brought it to the attention of the general community in natural sciences. Expertise in dissipative quantum mechanics is by now beneficial in a broad sphere. This book — originally published in 1992 and republished as enlarged and updated second, third and fourth edition in 1999, 2008, and 2012 — dives even deeper into the fundamental concepts, methods and applications of quantum dissipation. The fifth edition provides a self-contained and updated account of the quantum mechanics and quantum statistics of open systems. The subject matter of the book has been thoroughly revised to better comply with the needs of newcomers and the demands of the advanced readership. Most of the chapters are rewritten to enhance clarity and topicality. Four new chapters covering recent developments in the field have been added. There are about 600 references. This book is intended for use by advanced undergraduate and graduate students in physics, and for researchers active in the field. They will find the monograph as a rich and stimulating source. Sample Chapter(s) Preface Prefaces to former editions 1: Introduction Request Inspection Copy Contents: Introduction General Theory of Open Quantum Systems: Diverse Limited Approaches: A Brief Survey System-Plus-Reservoir Models Imaginary-Time Approach and Equilibrium Dynamics Real-Time Approach and Nonequilibrium Dynamics Miscellaneous Applications: Damped Linear Quantum Mechanical Oscillator Quantum Brownian Free Motion The Thermodynamic Variational Approach Suppression of Quantum Coherence Quantum Statistical Decay: Introduction Classical Rate Theory: A Brief Overview Quantum Rate Theory: Basic Methods Multidimensional Quantum Rate Theory Crossover from Thermal to Quantum Decay Thermally Activated Decay The Crossover Region Dissipative Quantum Tunneling The Dissipative Two-State System: Introduction Thermodynamics Electron Transfer and Incoherent Tunneling Two-State Dynamics: Basics and Methods Two-State Dynamics: Sundry Topics The Driven Two-State System The Dissipative Multi-State System: Quantum Brownian Particle in a Washboard Potential Multi-State Dynamics Exact Formal Expressions for Current and Current Noise The Ohmic Case Duality Symmetry Full Counting Statistics at Zero Temperature Twisted Partition Function and Nonlinear Mobility Charge Transport in Quantum Impurity Systems Nonlinear Quantum Brownian Duet as Work-to Work Converter Readership: Advanced undergraduate and graduate students; researchers in quantum statistical and condensed matter physics, in quantum/classical mechanics, in quantum information and quantum state engineering, in quantum optics, and in Bose-condensed systems.