Carbohydrate Recognition

This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.

Preface vii Contributors ix 1 Mammalian Glycan Biosynthesis: Building a Template for Biological Recognition 1 M. Adam Meledeo, Venkata D. P. Paruchuri, Jian Du, Zhiyun Wang, and Kevin J. Yarema 2 The Roles of Carbohydrate Binding in Cell Adhesion and Inflammation 33 Ken Kitajima and Chihiro Sato 3 The Role of Carbohydrates in Viral Infections 65 Gillian M. Air 4 The Role of Carbohydrates in Bacterial Infections 93 Roland J. Pieters 5 The Roles of Carbohydrate Binding in Fertilization 107 David J. Miller 6 Carbohydrate Biomarkers 133 Yunfeng Cheng, Nanting Ni, Hanjing Peng, Shan Jin, and Binghe Wang 7 Galectins and Their Role in Various Biological Processes 157 Sarika Saraswati, Ashley Stanley Block, and Alan B. Diekman 8 Glycoimmunology 181 Ani Grigorian, Barbara Newton, and Michael Demetriou 9 Tools For Glycomics: Glycan and Lectin Microarrays 205 Christopher Campbell and Jeff Gildersleeve 10 Combinatorial Biosynthesis of Complex Carbohydrates 229 Hai Yu and Xi Chen 11 Mass Spectrometry in Carbohydrate Sequencing and Binding Analysis 257 Gregory O. Staples and Joseph Zaia 12 Synthetic Lectin Mimics Artificial Carbohydrate Receptors 301 Xiaochuan Yang, Yunfeng (Jerry) Cheng, and Binghe Wang 13 Lectin Binding and Its Structural Basis 329 Annabelle Varrot, Bertrand Blanchard, and Anne Imberty 14 Multivalency in Carbohydrate Binding 349 Mark L. Wolfenden and Mary J. Cloninger 15 Carbohydrate Binding Agents: Potential Therapeutics with Multiple Inhibitory Actions Against Enveloped Viruses 371 K.O. François and J. Balzarini 16 Informatics for Glycobiology and Glycomics 409 Kiyoko F. Aoki-Kinoshita Index 427