Molecular Biology of Human Cancers (2版)

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This textbook describes the most relevant molecular and biological processes in cancer, how they contribute to the development and progression of individual cancer types in humans, and how insights from molecular cancer research can be applied to improve cancer prevention, diagnostics and treatment. Part I of the textbook summarizes the current fundamental knowledge on the general properties of cancers, the causes of cancer, cancer genetics, genomics and epigenetics. Individual chapters address the functions of DNA damage and repair, oncogenes and tumor suppressors in carcinogenesis and discuss crucial mechanisms in cancer pathogenesis, such as apoptosis and replicative senescence, as well as the most relevant signal transduction pathways and regulatory networks. Part I concludes with a chapter on tumor invasion and metastasis and tumor immunology. In Part II, the most relevant mechanisms acting in individual human cancers (and subtypes) are described in more detail. This central part of the book contains individual sections on the most common human cancers highlighting the diversity in their genetic, molecular and cellular pathogenic mechanisms. How insights from molecular cancer research are translated into improvements in prevention, diagnosis, and treatment is outlined in Part III. This new edition has been extensively revised and includes in particular updated information on cancer genomics, epigenetics, viral carcinogenesis, cancer diagnostics and cancer therapy and a new chapter on lung cancers. Now more than ever, cancer research is an interdisciplinary endeavor that requires a basic knowledge of commonly used terms, facts and concepts. The aim of this book is to provide advanced students and practitioners in various disciplines with this foundation, bridging the gap between standard textbooks of molecular biology, pathology and oncology on the one hand and the specialized cancer literature on the other.

Biochemistry and Cell Biology of Ageing: Part III Biomedical Science (1版)

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This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells. The reader is introduced to the historical development and progress in biomedical aging research and learns, for example, about the role of microRNAs, circRNAs, mitochondria and extracellular vesicles in cellular senescence. The reader will also learn more about how gap junctions, the nuclear pore complex and the proteasome are affecting the ageing processes. In addition, novel therapeutic opportunities through modulation of cellular senescence are discussed. The book follows on from Parts I and II of Biochemistry and Cell Biology of Ageing (Volumes 90 and 91 of the Subcellular Biochemistry book series) by covering interesting and significant biomedical ageing topics not included in the earlier volumes. Comprehensive and cutting-edge, this book is a valuable resource for experienced researchers and early career scientist alike, who are interested in learning more about the fascinating and challenging question of why and how our cells age.

Brock Biology of Microorganisms (16版)

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【簡介】 Get a solid understanding of the major concepts in microbiology with a textbook t hat offers cutting-edge research findings, powerful tools, and visuals. Brock Biology of Microorganisms, Global Edition, 16th Edition is the latest version of the most authoritative textbook in the field, offering powerful, accurate, yet accessible content surrounding the basic concepts of microbiology. The text guides you through the six major themes of microbiology ― Evolution, Cell Structure and Function, Metabolic Pathways, Information Flow and Genetics, Microbial Systems, and the Impact of Microorganisms ― as outlined by the American Society for Microbiology Conference on Undergraduate Education (ASMCUE). Following a modern robust approach, the book supports your knowledge of the genomics and other omics" maze - concepts that are fundamental to the field and have transformed and revolutionised microbiology. Furthermore, it provides concrete examples of how powerful tools have allowed microbiologists to probe deeper and further into the microbial world than ever before. 【目錄】

The Biology of Cancer (3版)

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內容簡介 Incorporating the most important advances in the rapidly-evolving field of cancer biology, this book remains the defining course text on its subject. Students, instructors, researchers, and clinicians the world over admire its authoritative content, clear explanations, extensive full-color art program, and pedagogical features that promote a deep conceptual understanding of the science through the lens of fascinating tales of scientific discovery. 目次 Chapter 1: The Biology and Genetics of Cells and Organisms Chapter 2: The Nature of Cancer Chapter 3: Cancer as an Infectious Disease Chapter 4: Cellular Oncogenes Chapter 5: Growth Factors, Receptors, and Cancer Chapter 6: Cytoplasmic Signaling Circuitry Programs Many of the Traits of Cancer Chapter 7: Tumor Suppressor Genes Chapter 8: pRb and Control of the Cell Cycle Clock Chapter 9: p53: Master Guardian and Executioner Chapter 10: Eternal Life: Cell Immortalization and Tumorigenesis Chapter 11: Multi-Step Tumorigenesis Chapter 12: Shaping and Characterizing the Cancer Genome Chapter 13: Dialogue Replaces Monologue: Heterotypic Interactions and the Biology of Angiogenesis Chapter 14: Moving Out: Invasion and Metastasis Chapter 15: Crowd Control: Tumor Immunology Chapter 16: Cancer Immunotherapy Chapter 17: The Rational Treatment of Cancer Supplementary Sidebars